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Flashcards in Natural Products Deck (13)
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1
Q

What is the MOA of vinca alkaloids and what phase of the cell cycle do they affect?

A

Inhibit tubular polymerization

M phase

2
Q

What is the adverse effect of vinblastine and what 3 cancers does it treat?

A

Severe blisters

HL, NHL, and breast cancer

3
Q

Adverse effect of vincristine and what 3 categories of cancers does it treat?

A

SIADH
CLL
Hematologic cancers
Pediatric tumors

4
Q

3 cancers we use vinorelbine to treat?

A

NSCLC, breast and ovarian

5
Q

MOA for taxanes and antibicrotubules and what phase of the cell cycle does it affect?

A

Enhance tubule polymerization which inhibits m phase

6
Q

What category of tumors do we use paclitaxel for and name 3 specific?

A

Broad range of solid tumors.

Breast, ovary, and lung

7
Q

Docetaxel is approved for use in what 2 cancers and is what line of therapy in those cancers?

A

Second line therapy in breast and NSCLC

8
Q

What is the unique use for cabazitaxel and why?

A

Poor substrate for PGP so this is helpful in multi drug resistant tumors

9
Q

MOA of Ipabexilone and eribulin, what type of tumors can these guys go after, and what is one cancer they are both approved for?

A

B analog, so inhibits microtubule function
Less sensitive to PGP so if a tumor overexpresses PGP, this is good
Metastatic breast cancer

10
Q

MOA of etoposide and 4 cancers it is used against?

A

Topoisomerase 2 blocker

Germ cell, lung, HL and NHL

11
Q

MOA for topotecan and 2 cancers to treat with it?

A

Topo 1 blocker

Second line therapy for ovarian and small cell lung cancer

12
Q

MOA for irinotecan and 1 cancer to treat with it?

A

Topo 1 blocker

Adenocarcinoma of the pancreas. Use with 5FU

13
Q

What two MOAs am I thinking about with natural cancer drugs?

A

Either inhibit of enhance microtubules

Inhibit topo 1 and 2