What is the MOA of vinca alkaloids and what phase of the cell cycle do they affect?
Inhibit tubular polymerization
What is the adverse effect of vinblastine and what 3 cancers does it treat?
HL, NHL, and breast cancer
Adverse effect of vincristine and what 3 categories of cancers does it treat?
3 cancers we use vinorelbine to treat?
NSCLC, breast and ovarian
MOA for taxanes and antibicrotubules and what phase of the cell cycle does it affect?
Enhance tubule polymerization which inhibits m phase
What category of tumors do we use paclitaxel for and name 3 specific?
Broad range of solid tumors.
Breast, ovary, and lung
Docetaxel is approved for use in what 2 cancers and is what line of therapy in those cancers?
Second line therapy in breast and NSCLC
What is the unique use for cabazitaxel and why?
Poor substrate for PGP so this is helpful in multi drug resistant tumors
MOA of Ipabexilone and eribulin, what type of tumors can these guys go after, and what is one cancer they are both approved for?
B analog, so inhibits microtubule function
Less sensitive to PGP so if a tumor overexpresses PGP, this is good
Metastatic breast cancer
MOA of etoposide and 4 cancers it is used against?
Topoisomerase 2 blocker
Germ cell, lung, HL and NHL
MOA for topotecan and 2 cancers to treat with it?
Topo 1 blocker
Second line therapy for ovarian and small cell lung cancer
MOA for irinotecan and 1 cancer to treat with it?
Topo 1 blocker
Adenocarcinoma of the pancreas. Use with 5FU
What two MOAs am I thinking about with natural cancer drugs?
Either inhibit of enhance microtubules
Inhibit topo 1 and 2