Antimicrobials Flashcards Preview

Infectious Disease Unit 1 > Antimicrobials > Flashcards

Flashcards in Antimicrobials Deck (29)
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1

Prototypical Penicillins

Penicillin G, penicillin V

2

Penicillinase resistant penicillins

Methicillin, Oxacillin

(dicloxacillin, cloxacillin)

3

Extended spectrum penicillins

Amoxicillin, Ampicillin

4

Antipseudomonal penicillins

Piperacillin

(Ticarcillin, Mezlocillin, Carbenicillin)

5

Penicillin plus beta-lactamase inhibitor combos

-Amoxicillin/clavulanate (Augmentin)
- Piperacillin/Tazobactam


(Ampicillin/Sulbactam; Ticarcillin/Clavulanate)

6

How many cephalosporin generations

5

7

1st gen cephalosporins

-Cephalexin, Cefazolin

(Cephradine, Cefadroxil)

8

2nd gen cephalosporins

Cefuroxime, Cefaclor

(Cefotetan, Cefoxitin, Cefprozil, Locarbef, Cefmetazole, Cefonicid)

9

3rd gen cephalosporins

-Ceftriaxone, Ceftazidime, Cefdinir, Cefepime

(Cefotaxime, Cefoperazone, Cefixime, Cefpodoxime, Ceftibutin, Ceftizoxime)

10

Carbapenems

-Imipenem/Cilastatin, Ertapenem

(Meropenem)

11

Monobactams

Aztreonam

12

Cell wall synthesis inhibitors

Penicillins, Cephalosporins, Carbapenems, Monobactams, Vancomycin

13

Protein synthesis inhibitors

Aminoglycosides
Tetracyclines
Macrolides
Lincomycins
Synthetic agents
Streptogramins
Oxazolidinones
Spectinomycin

14

Aminoglycosides

-Tobramycin, Gentamicin

(Amikacin, Netilmicin, Paromomycin, Streptomycin)

15

Tetracyclines

"-cyclines"
-Tetracycline,
Doxycycline, Minocycline

(Demeclocycline, Methacycline, Oxytetracycline, Tigecycline)

16

Macrolides

"-mycins"
- Erythromycin, Azithromycin, Clarithromycin

(telithromycin, dirithromycin, troleandomycin)

17

Lincomycins

Clindamycin

18

Synthetic agents

Chloramphenicol

19

Streptogramins

Quinupristin/Dalfopristin

20

Oxazolidinones

Linezolid

21

Inhibitors of Intermediary Metabolism

Sulfonamides

22

Sulfonamides

Sulmethoxazole/Trimethoprim

23

Interference with nucleic acid processing

Quinolones
Fluoroquinolones

24

Quinolones & Fluoroquinolones

= "xacin"
-Ciprofloxacin, Levofloxacin, Moxifloxacin

(Cinoxacin, Enoxacin, Nalidixic acid, Gemifloxacin, Lomefloxacin, Norfloxacin, Ofloxacin)

25

Beta-lactam drugs

penicillins, cephalosporins, carbapenems, monobactams, vancomycin, bacitracin, cycloserine (TB)

26

Antimetabolites

trimethoprim, sulfonamides, sulfones

- affect folic acid metabolism

27

Sulfonamides MOA

inhibit dihydropteroate synthase (first step in folic acid synthesis)
- bacteriostatic

28

Trimethoprim MOA

act at 3rd step of folic acid synthesis to inhibit dihydrofolate reductase
- faster action than sulfonamides

29

Sulfonamides resistance mechanism

- acquired, bypass