Antimicrobials 7-8

Question 1

WHAT ARE THE 50S INHIBITORS

Answer 1

Macrolides
Lincosamides
Chloramphenicol

Question 2

“methylated ervthromycin”

Answer 2

Clarithromycin

Question 3

What are the macrolides drugs

Answer 3

Clarithromycin
Azithromycin
Roxithromycin
Erythromycin

Question 4

prototype, produced from S. erythraeus,

Answer 4

Erythromycin

Question 5

use: for the treatment of ulcers caused by H. pylori

Answer 5

Clarithromycin

Question 6

potent enzyme inhibitors

Answer 6

Clarithromycin & Erythromycin

Question 7

14-16-membered macrocyclic lactone ring

Answer 7

Macrolides

Question 8

Other term of Erythromycin

Answer 8

Ilotycin

Question 9

a prodrug which is more lipophilic >- longer duration of action

Answer 9

ethylsuccinate

Question 10

A type of pneumonia caused by legionella pneumop

Answer 10

Legionnaire’s disease

Question 11

sulfur-containing antibiotic

Answer 11

Lincosamides

Question 12

lipid-soluble, acid-stable prodrug with better oral absorption

Answer 12

estolate

Question 13

motilin agonist

Answer 13

Erythromycin

Question 14

isolated from Streptomyces lincolnensis

Answer 14

Lincomycin

Question 15

from Streptomyces venezuelae

Answer 15

Chloramphenicol

Question 16

70S Inhibitor

Answer 16

Oxazolidinone antibacterial

Question 17

idiosyncratic reaction unrelated to dose

Answer 17

aplastic anemia:

Question 18

old DOC for typhoid fever

Answer 18

Chloramphenicol

Question 19

A/E C. difficile-induced pseudomembranous colitis

Answer 19

Clindamycin

Question 20

Lincosamides drugs

Answer 20

Lincomycin
Clindamycin

Question 21

DOC: VRSA

Answer 21

Linezolid

Question 22

chlorine-substituted derivative of lincomycin

Answer 22

Clindamycin

Question 23

rapidly absorbed and wel tolerated oraly but should not be administered with food and antacids

Answer 23

Azithromycin

Question 24

a 15-membered lactone ring with N-methyl group

Answer 24

Azithromycin

Question 25

Hydrate forms of azithromycin

Answer 25

dehydrate monohydrate

Question 26

extensive tissue distribution - allows once a day dosing

Answer 26

Azithromycin

Question 27

weak enzyme inhibitor

Answer 27

Roxithromycin

Question 28

NOT an enzyme inhibitor

Answer 28

Azithromycin

Question 29

Brand name of hydrtae form of azithromycin

Answer 29

- dehydrate (Zithromax®) - monohydrate (Azyth ®)

Question 30

Remedy of a bitter taste of clarithromycin

Answer 30

Addition of palmitic acid (prodrug)

Question 31

last-resort drug

Answer 31

Linezolid

Question 32

DOC: Legionnaire's disease

Answer 32

Erythromycin

Question 33

patterned after nalidixic acid

Answer 33

Quinolones

Question 34

SAR of Quinolones: addition of groups greatly reduces or abolishes activity

Answer 34

At 2

Question 35

SAR of Quinolones: may be substituted with good effects

Answer 35

at 5, 6, 7, 8,

Question 36

SAR of Quinolones: small alkyl substitution provides greater potency

Answer 36

at 1

Question 37

SAR of Quinolones: increases antibacterial activity

Answer 37

At 6, + fluoroquinilines

Question 38

SAR of Quinolones: provides activity against Pseudomonas aeruginosa

Answer 38

At 7, + Piperacillin

Question 39

side effect is photosensitivity HIGHEST

Answer 39

Lomefloxacin

Question 40

side effect is photosensitivity LOWEST in Quinolones

Answer 40

Sparfloxacin

Question 41

DOC: prophylaxis and treatment of anthrax

Answer 41

Ciprofloxacin

Question 42

SAR: nitro a t 5 t position is essential for antibacterial activity

Answer 42

Nitrofurans

Question 43

What are the Nitrofurans Drugs

Answer 43

Nitrofurantoin Nitrofurazone Furazolidone

Question 44

used topically in burns

Answer 44

Nitrofurazone

Question 45

oral treatment used for bacterial and protozoal diarrhea

Answer 45

Furazolidone

Question 46

used topically in burns

Answer 46

Nitrofurazone

Question 47

inhibits DNA gyrase & Topoisomerase IV

Answer 47

MOA if quinolones

Question 48

Nucleus of quinolones

Answer 48

1,4 dihydro-4-oxo-3 pyridine carboxylic acid

Question 49

Retained G(-), G(+), and atypical bacteria activity: also has an activity against anaerobic bacteria

Answer 49

Trovafloxacin