Antineoplastics Flashcards by Adam Sattler

Q

cladribine indication

A

hairy cell leukemia

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Q

gemcitabine

A

inhibit DNA pol
pyrimidine

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Q

cytarabine

A

inhibit DNA pol
pyrimidine

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Q

cladribine

A

inhibit DNA pol
purine

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Q

AMP, GMP

A

purine nucleotides

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Q

azathioprine

A

6-MP prodrug

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Q

6-MP is activated by ___

A

HGPRT

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Q

6-MP MOA

A

blocks IMP synthesis
(and thus AMP, GMP production)

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Q

6-MP indications

A

ALL
IBS
RA (refractory)

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Q

6-MP is inactivated by ___ and ___

A

XO
TPMT

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Q

mycophenolate mofetil

A

IMP dehydrogenase inhibitor

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Q

6-MP adverse effects

A

pancreatitis
hepatitis
myelosuppression

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Q

cyclophosphamide

A

DNA alkylating (cross-linking) agent

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Q

how to activate cyclophosphamide

A

CYP 450

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Q

cyclophosphamide adverse effects

A

hemorrhagic cystitis
SIADH
infertility

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Q

___ prevents hemorrhagic cystitis with cyclophosphamide use

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A

mesna

Q

cyclophosphamide increases risk for ___ ___

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A

bladder cancer

Q

busulfan

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A

transplant immunosuppresant
DNA alkylating agent

Q

streptozocin indication

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A

GBM
(easily cross BBB)

Q

INF-B indication

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A

MS

Q

INF-gamma indication

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A

CGD

Q

-platin MOA

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A

cross-link with platinum

Q

antineoplastic that causes ototoxicity

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A

cisplatin

Q

cisplatin is ___toxic

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A

nephro
(and ototoxic)

___ prevents cisplatin-induced nephrotoxicity

amifostine

amifostine MOA

free radical scavenger

-poside

topoisomerase II inhibitors

-tecan

topoisomerase I inhibitors

-taxel MOA

prevent microtubule degradation and increase improper production