Neuro

Question 1

methadone advantage

Answer 1

long half-life
mu agonist

Question 2

buprenorphine disadvantage

Answer 2

partial mu agonist
(can precipitate withdrawal)

Question 3

naltrexone relevance

Answer 3

substance abstinence

Question 4

ketamine

Answer 4

NMDA antagonist
dissociative amnesia
preserves lung function
analgesia

Question 5

propofol adverse effects

Answer 5

increased TGs
anaphylaxis (soy and egg)
vasodilation
respiratory depression

Question 6

etomidate

Answer 6

hemodynamically stable!
adrenal suppression

Question 7

anesthetic with analgesic effects

Answer 7

ketamine

Question 8

anesthetic that causes catecholamine release

Answer 8

ketamine

Question 9

valproate MOA

Answer 9

blocks Na and Ca (T) channels
increases GABA levels

Question 10

valproate adverse effects

Answer 10

hyperammonemia (hepatotoxicity)
weight gain

Question 11

valproate teratogenicity

Answer 11

NT defects

Question 12

topiramate MOA

Answer 12

blocks Na channels
allosterically binds GABA-A

Question 13

topiramate adverse effects

Answer 13

nephrolithiasis
weight loss
glaucoma

Question 14

lamotrigine

Answer 14

blocks Na channel

Question 15

lamotrigine adverse effects

Answer 15

SJS-TEN
diplopia

Question 16

levetiracetam

Answer 16

bind SV2A (glycoprotein 2A)

Question 17

which antiepileptic not metabolized by CYP450?

Answer 17

levetiracetam

Question 18

broad spectrum antiepileptics (4)

Answer 18

valproate
topiramate
lamotrigine
levetiracetam

Question 19

pregabalin (gabapentin)

Answer 19

block Ca channels

Question 20

postherpetic neuralgia Tx

Answer 20

gabapentin

Question 21

FGAs MOA

Answer 21

D2 receptor blockers
H1 blockade

Question 22

FGA adverse effects (4)

Answer 22

extrapyramidal symptoms
tardive dyskinesia
QT prolongation
metabolic syndrome

Question 23

haloperidol adverse effects (2)

Answer 23

galactorrhea
neuroleptic malignant syndrome

Question 24

thioridazine

Answer 24

low potency FGA
retinal deposits

Question 25

chlorpromazine

Answer 25

low potency FGA corneal deposit

Question 26

FGAs and SGAs have ___ receptor antagonism

Answer 26

H1 (anticholinergic symptoms)

Question 27

FGA indications

Answer 27

agitation mania schizophrenia

Question 28

tourette Tx (SGAs)

Answer 28

risperidone

Question 29

SGAs MOA

Answer 29

D2 receptor blockers 5-HT 2A blockers H1 blockade A1 antagonism

Question 30

negative schizophrenia symptom Tx

Answer 30

SGAs

Question 31

other clozapine adverse effects (3)

Answer 31

agranulocytosis cardiomyopathy seizures (in addition to anticholinergic and metabolic effects)

Question 32

SGA most similar to FGAs

Answer 32

risperidone

Question 33

___ increases DA levels in the CNS

Answer 33

selegiline

Question 34

ropinarole

Answer 34

DA-2 agonist

Question 35

pramipexole

Answer 35

DA-3 agonist (CNS)

Question 36

amantadine

Answer 36

enhances endogenous DA effects

Question 37

serotonin syndrome Tx

Answer 37

cyproheptadine

Question 38

baclofen

Answer 38

GABA-B agonist

Question 39

cyclobenzaprine

Answer 39

central-acting skeletal muscle relaxant

Question 40

cyclobenzaprine adverse effect

Answer 40

anticholinergic effects

Question 41

dantrolene MOA

Answer 41

blocks ryanodine receptor Ca release

Question 42

dantrolene indications

Answer 42

NMS malignant hyperthermia

Question 43

-pramine

Answer 43

TCA

Question 44

-triptyline

Answer 44

TCA

Question 45

tranylcypromine

Answer 45

MAO-I

Question 46

phenelzine

Answer 46

MAO-I

Question 47

isocarboxazid

Answer 47

MAO-I

Question 48

tyramine toxicity Tx

Answer 48

phentolamine

Question 49

bupropion contraindications

Answer 49

bulimia and anorexia (cause seizures)

Question 50

bupropion MOA

Answer 50

NET and DAT inhibitor

Question 51

which diuretics increase lithium levels?

Answer 51

thiazide

Question 52

lithium adverse effects (3)

Answer 52

nephrogenic DI hypothyroidism ebstein anomaly (atrialization of RV)

Question 53

trigeminal neuralgia Tx

Answer 53

carbamazepine

Question 54

what tests must be conducted for carbamazepine?

Answer 54

CBC (due to agranulocytosis risk)

Question 55

vigabatrin

Answer 55

inhibit GABA transaminase

Question 56

tiagabine

Answer 56

inhibits GABA reuptake