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Sketchy Pharm > Neuro > Flashcards

Neuro Flashcards

1
Q

methadone advantage

A

long half-life
mu agonist

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2
Q

buprenorphine disadvantage

A

partial mu agonist
(can precipitate withdrawal)

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3
Q

naltrexone relevance

A

substance abstinence

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4
Q

ketamine

A

NMDA antagonist
dissociative amnesia
preserves lung function
analgesia

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5
Q

propofol adverse effects

A

increased TGs
anaphylaxis (soy and egg)
vasodilation
respiratory depression

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6
Q

etomidate

A

hemodynamically stable!
adrenal suppression

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7
Q

anesthetic with analgesic effects

A

ketamine

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8
Q

anesthetic that causes catecholamine release

A

ketamine

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9
Q

valproate MOA

A

blocks Na and Ca (T) channels
increases GABA levels

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10
Q

valproate adverse effects

A

hyperammonemia (hepatotoxicity)
weight gain

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11
Q

valproate teratogenicity

A

NT defects

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12
Q

topiramate MOA

A

blocks Na channels
allosterically binds GABA-A

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13
Q

topiramate adverse effects

A

nephrolithiasis
weight loss
glaucoma

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14
Q

lamotrigine

A

blocks Na channel

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15
Q

lamotrigine adverse effects

A

SJS-TEN
diplopia

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16
Q

levetiracetam

A

bind SV2A (glycoprotein 2A)

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17
Q

which antiepileptic not metabolized by CYP450?

A

levetiracetam

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18
Q

broad spectrum antiepileptics (4)

A

valproate
topiramate
lamotrigine
levetiracetam

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19
Q

pregabalin (gabapentin)

A

block Ca channels

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20
Q

postherpetic neuralgia Tx

A

gabapentin

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21
Q

FGAs MOA

A

D2 receptor blockers
H1 blockade

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22
Q

FGA adverse effects (4)

A

extrapyramidal symptoms
tardive dyskinesia
QT prolongation
metabolic syndrome

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23
Q

haloperidol adverse effects (2)

A

galactorrhea
neuroleptic malignant syndrome

24
Q

thioridazine

A

low potency FGA
retinal deposits

25
Q

chlorpromazine

A

low potency FGA
corneal deposit

26
Q

FGAs and SGAs have ___ receptor antagonism

A

H1 (anticholinergic symptoms)

27
Q

FGA indications

A

agitation
mania
schizophrenia

28
Q

tourette Tx (SGAs)

A

risperidone

29
Q

SGAs MOA

A

D2 receptor blockers
5-HT 2A blockers
H1 blockade
A1 antagonism

30
Q

negative schizophrenia symptom Tx

A

SGAs

31
Q

other clozapine adverse effects (3)

A

agranulocytosis
cardiomyopathy
seizures

(in addition to anticholinergic and metabolic effects)

32
Q

SGA most similar to FGAs

A

risperidone

33
Q

___ increases DA levels in the CNS

A

selegiline

34
Q

ropinarole

A

DA-2 agonist

35
Q

pramipexole

A

DA-3 agonist (CNS)

36
Q

amantadine

A

enhances endogenous DA effects

37
Q

serotonin syndrome Tx

A

cyproheptadine

38
Q

baclofen

A

GABA-B agonist

39
Q

cyclobenzaprine

A

central-acting skeletal muscle relaxant

40
Q

cyclobenzaprine adverse effect

A

anticholinergic effects

41
Q

dantrolene MOA

A

blocks ryanodine receptor Ca release

42
Q

dantrolene indications

A

NMS
malignant hyperthermia

43
Q

-pramine

A

TCA

44
Q

-triptyline

A

TCA

45
Q

tranylcypromine

A

MAO-I

46
Q

phenelzine

A

MAO-I

47
Q

isocarboxazid

A

MAO-I

48
Q

tyramine toxicity Tx

A

phentolamine

49
Q

bupropion contraindications

A

bulimia and anorexia
(cause seizures)

50
Q

bupropion MOA

A

NET and DAT inhibitor

51
Q

which diuretics increase lithium levels?

A

thiazide

52
Q

lithium adverse effects (3)

A

nephrogenic DI
hypothyroidism
ebstein anomaly (atrialization of RV)

53
Q

trigeminal neuralgia Tx

A

carbamazepine

54
Q

what tests must be conducted for carbamazepine?

A

CBC (due to agranulocytosis risk)

55
Q

vigabatrin

A

inhibit GABA transaminase

56
Q

tiagabine

A

inhibits GABA reuptake

Sketchy Pharm (7 decks)

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