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Sketchy Pharm > Endocrine > Flashcards

Endocrine Flashcards

1
Q

-gliptin

A

DPP-4 inhibitors
(glucose-dependent)

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2
Q

sulfonureas

A

-amide
-ride
-zide

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3
Q

insulin effect on Na/K ATPase

A

increases activity
(causes hypokalemia)

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4
Q

rapid-acting insulin

A

glulisine
aspart
lispro

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5
Q

long-acting insulin

A

detemir
glargine

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6
Q

IV insulin potential adverse effect

A

hypokalemia
(can treat hyperkalemia)

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7
Q

-glinide (meglitinide)

A

NOT sulfonurea, but same MOA
(glucose-independent)

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8
Q

-tide

A

GLP-1 agonist

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9
Q

-gliptin adverse effects

A

URIs

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10
Q

___ inhibits glycerol-3-phosphate dehydrogenase

A

metformin (decreases gluconeogenesis)

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11
Q

___ activates AMP protein kinase

A

metformiin

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12
Q

___ increases insulin sensitivity

A

metformin

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13
Q

which T2DM agent is contraindicated in CHF patients?

A

thiazolidinediones

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14
Q

pramlintide

A

amylin analog
(T1 and T2 indications)

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15
Q

acarbose

A

a-glucosidase inhibitor

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16
Q

miglitol

A

a-glucosidase inhibitor

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17
Q

GH pathway

A

JAK-STAT

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18
Q

GH indications

A

prader willi
turner syndrome

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19
Q

mecasermin

A

recombinant IGF-1

20
Q

VIPoma Tx

A

octreotide

21
Q

carcinoid tumor symptom Tx

A

octreotide

22
Q

insulinoma Tx

A

octreotide

23
Q

glucagonoma Tx

A

octreotide

24
Q

gastrinoma Tx

A

octreotide

25
Q

esophageal bleeding Tx

A

octreotide
DDAVP

26
Q

pegvisomat

A

GH receptor antagonist

27
Q

V1 receptor is coupled to G_

A

Gq
(causes vasoconstriction)

28
Q

V2 receptor is coupled to G_

A

Gs
(causes AQP-2 translocation)

29
Q

V2 activation on endothelium

A

vWF and factor VIII release

30
Q

lithium can cause ___ ___

A

nephrogenic DI

31
Q

nephrogenic DI Tx

A

amiloride (best for lithium-induced)
thiazides
NSAIDs

32
Q

central DI Tx

A

DDAVP

33
Q

vWF disease Tx

A

DDAVP

34
Q

nocturnal enuresis Tx

A

DDAVP

35
Q

-vaptan

A

V2 receptor antagonists

36
Q

SIADH Tx

A

-vaptan

37
Q

demeclocycline relevance

A

SIADH Tx (outdated)

38
Q

primary hyperparathyroidism Tx

A

cinacalcet

39
Q

cinacalcet

A

CaSR activator

40
Q

sevelamer

A

phosphate binder

41
Q

hyperphosphatemia (CKD) Tx

A

sevelamer

42
Q

most sever adverse effect of PTU and methimazole

A

agranulocytosis

43
Q

___ is a first trimester teratogen
(think hyperthyroidism Tx)

A

methimazole

44
Q

perchlorate, pertechnetate

A

inhibit Na/I symporter

45
Q

exopthalmos Tx

A

glucocorticoids

Sketchy Pharm (7 decks)

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