Endocrine Flashcards by Adam Sattler

Q

-gliptin

A

DPP-4 inhibitors
(glucose-dependent)

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Q

sulfonureas

A

-amide
-ride
-zide

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Q

insulin effect on Na/K ATPase

A

increases activity
(causes hypokalemia)

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Q

rapid-acting insulin

A

glulisine
aspart
lispro

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Q

long-acting insulin

A

detemir
glargine

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Q

IV insulin potential adverse effect

A

hypokalemia
(can treat hyperkalemia)

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Q

-glinide (meglitinide)

A

NOT sulfonurea, but same MOA
(glucose-independent)

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Q

-tide

A

GLP-1 agonist

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Q

-gliptin adverse effects

A

URIs

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Q

___ inhibits glycerol-3-phosphate dehydrogenase

A

metformin (decreases gluconeogenesis)

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Q

___ activates AMP protein kinase

A

metformiin

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Q

___ increases insulin sensitivity

A

metformin

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Q

which T2DM agent is contraindicated in CHF patients?

A

thiazolidinediones

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Q

pramlintide

A

amylin analog
(T1 and T2 indications)

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Q

acarbose

A

a-glucosidase inhibitor

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Q

miglitol

A

a-glucosidase inhibitor

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Q

GH pathway

A

JAK-STAT

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Q

GH indications

A

prader willi
turner syndrome

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Q

mecasermin

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A

recombinant IGF-1

Q

VIPoma Tx

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A

octreotide

Q

carcinoid tumor symptom Tx

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A

octreotide

Q

insulinoma Tx

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A

octreotide

Q

glucagonoma Tx

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A

octreotide

Q

gastrinoma Tx

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A

octreotide

esophageal bleeding Tx

octreotide DDAVP

pegvisomat

GH receptor antagonist

V1 receptor is coupled to G_

Gq (causes vasoconstriction)

V2 receptor is coupled to G_

Gs (causes AQP-2 translocation)

V2 activation on endothelium

vWF and factor VIII release

lithium can cause ___ ___

nephrogenic DI

nephrogenic DI Tx

amiloride (best for lithium-induced) thiazides NSAIDs

central DI Tx

DDAVP

vWF disease Tx

DDAVP

nocturnal enuresis Tx

DDAVP

-vaptan

V2 receptor antagonists

SIADH Tx

-vaptan

demeclocycline relevance

SIADH Tx (outdated)

primary hyperparathyroidism Tx

cinacalcet

cinacalcet

CaSR activator

sevelamer

phosphate binder

hyperphosphatemia (CKD) Tx

sevelamer

most sever adverse effect of PTU and methimazole

agranulocytosis

___ is a first trimester teratogen (think hyperthyroidism Tx)

methimazole

perchlorate, pertechnetate

inhibit Na/I symporter

exopthalmos Tx

glucocorticoids