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Flashcards in Antiparasitic Agents Deck (42):
1

Chloroquine MOA

Prevents polymerization of heme

2

Chloroquine SE

pruritis

3

Where are chloroquine susceptible P. falciparum found?

Central America, Caribbean, Middle East

4

Mefloquine Indication

Prophylaxis and treatment of all forms of malaria (including chloroquine resistant p. fal)

5

Mefloquine SE

Neuropsychiatric toxicity (black box warning)

6

Malarone (Atovaquone + Proguanil) MOA

Inhibits parasite mitochondrial electron transport

7

Malarone (Atovaquone + Proguanil) Indications

Better tolerated than mefloquine for prophylaxis

8

Doxycycline MOA

Protein syntesis inhibition

9

Doxycycline Indication

DOC for prophylaxis against mefloquine-resistant p. fal

10

Doxycycline SE

Dental issues (DO NOT give to pregnant or children)

11

Quine and Quinidine Indication

Severe disease with chloroquine resistant p. fal
Must use with 2nd agent (doxycycline)

12

Quinine and Quinidine SE

Cinchonism (headache, nausea, visual disturbance, tinnitus, dizzy)

13

What is safe in pregnant?

Quinine

14

Primaquine Indication

Exoerythrocytic forms of vivax and ovale

15

Primaquine Contraindications

G6PD deficiency > hemolysis

16

Artemisinin MOA

production of toxic free radicals in parasite food vacuole

17

ACT: Artimisinin combination therapy

Use with mefloquine

18

Chloroquine Indication

Prophylaxis: only in areas without resistant p. falciparum
Treatment: p. malariae, p. vivax and p. ovale (add primaquine), CQ sensitive p. fal

19

Treatment of CQ-sensitive p. fal

Cloroquine

20

Treatment of p. vivax and ovale

Chloroquine + Primaquine

21

Treatment of CQ-R p. fal, uncomplicated

Atovaquone-proguanil (malarone)
Artemether-lumefantrine (Coartem)
Quinine + doxy, tetra, clinda
Mefloquine

22

Malaria Prevention

CQ (w/o res p. fal)
Mefloquine
Atovaquone + proguanil (malarone)
Doxycycline
Primaquine (p. vivax, ovale)

23

Treatment of CQ-R p. fal, complicated

Quinidine + doxy, clinda
Artemisinin drugs
Transfusion if parasite >10%

24

Complicated malaria defintion

coma, severely altered mental status, parasitemia >5%, seizures, respiratory distress, shock

25

Rx Amebiasis

Asymptomatic: Iodoquinol or Paromomycin
Colitis, liver abscess, ameboma: metronidazole + luminal agent

26

Rx Giardiasis

Metronidazole, nitazoxanide, albendazole

27

Rx Cryptosporidiosis

Restore immune response in HIV
Nitazoxanide

28

Rx Toxoplasmosis

Pyrimethamine + Sulfadiazine or clinda

29

Rx Leishmaniasis

Sodium Stibogluconate
Amphotericin B

30

Rx Trypanosomiasis

African: Suramin, melarsoprol,
American: Nifurimox

31

Nifurtimox AE

COMMON: GI, rash, CNS

32

Rx Neurocysticercosis (taenia solium)

Albendazole, Praziquantel

33

Albendazole SE

Elevated aminotransferases, GI effects

34

Praziquantel CI

ocular cysticercosis

35

Mebendazole CI

first trimester, children under two

36

Pyrantel Pamoate Indication

pinworm, ascaris, hookworm

37

Pyrantel Pamoate MOA

depolarizing neuromuscular blocking > worm paralysis

38

Rx Filariasis

Diethylcarbamazine

39

Rx Onchoceriasis

Ivermectin

40

Ivermectin Indication

Strongyloidiasis and onchocerciasis

41

Ivermectin MOA

Paralyzes nematodes/arthropods (GABA mediated signals)

42

Ivermectin AE

Hypersensitivity from worm death (Mazotti reaction)