Chemotherapy I Flashcards Preview

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Flashcards in Chemotherapy I Deck (22):
1

Skipper Hypothesis

The ability of chemotherapy to cure is inversely proportional to the tumor burden

2

Cytotoxicity

= efficacy of the drug (in killing cancer cells)

3

Toxicity

= side effects

4

Partial remission

>50% reduction in tumor burden

5

Phase I clinical trials

determine dose and dose limiting toxicity

6

Phase II clinical trials

Determine Activity

7

Phase III clinical trials

Determine efficacy

8

Constitutional toxicities

Nausea, vomiting
Loss of appetitie
Fatigue

9

Toxicities due to effect on normal dividing cells

Myelosuppression
Temporary hair loss
Mucositis, sore mouth
Diarrhea
Sterility
Menopause
Secondary neoplasms

10

Organ specific toxicity of anthracyclines (doxorubicin)

Cardiac toxic

11

Organ specific toxicity of Bleomycin

Pulmonary toxicity

12

Organ specific toxicity of cis-DDP (cisplatin)

Nephrotoxicity

13

Absolute neutrophil count

White blood cell count x (%neutrophils + % bands)

14

Nadir

Lowest neutrophil count
10-14 days after dose

15

What can you give to prevent neutropenia?

Colony stimulating factors
Filgrastim (G-CSF)
*DO NOT start after already neutropenic

16

Febrile neutropenia

ANC less than 500, fever greater than 100.5 F
give broad spec Antibiotics

17

Thrombocytopenia

platelet transfusion if less than 10,000 or low platelet count at any levels and patient is bleeding

18

Anemia

Blood transfusions

19

Agents to give for nausea/vomiting

*ONDANSETRON
prochlorperazine
Selective serotonin antagonists
Corticosteroids
Lorazepam (anticipatory)
Aprepitant

20

Side effects of anti-emetics
Dexamethason:
Compazine:
Ondansetron:

Dexamethason: elevated sugars
Compazine: Extrapyramidal
Ondansetron: prolonged QT

21

Stomatitis

Inflammation of mucus membranes of mouth
Give magic mouthwash
+/- nystatin for oral fungal infection
Self-limiting

22

Vesicants

A substance that causes tissue blistering
Ex. viscristine, vinblastine, doxorubicin, daunorubicin
Portacath