Androgens Flashcards Preview

Pharm > Androgens > Flashcards

Flashcards in Androgens Deck (27):
1

Where are androgens synthesized?

95% testis (Leydig cells)
5% adrenal glands

2

Androgens are synthesized by circulating____

cholesterol

3

What are the metabolic effects of androgens?

Erythropoiesis
Decreased synthesis of clotting factors
Decrease HDL, increase LDL

4

Therapeutic uses of androgens

HRT in primary or secondary hypogonadism
Induction of puberty in delayed matruation
Osteoporosis in males

5

Testosterone enanthate/ Testosterone cypionate
Indication

Hypogonadism

6

Testosterone enanthate/ Testosterone cypionate
MOA (i.e. effects on the body)

Growth/maturation of prostate, seminal vesicles, penis, scrotum
Development of male hair distribution
Laryngeal development
Vocal cord thickening
Alterations in body musculature
Fat distribution

7

Testosterone enanthate/ Testosterone cypionate
Side Effects

Cholestatic jaundice syndrome
Liver carcinoma
Benign prostatic hyperplasia
Prostate cancer
Gynecomastia
Acne
Headache

8

Testosterone enanthate/ Testosterone cypionate
Contraindications

Breast cancer in men
Prostate cancer
Pregnancy

9

Testosterone enanthate/ Testosterone cypionate
Which route of administration is preferred?

Transdermal to prevent first pass hepatic metabolism

10

Androgen Receptor Antagonists

Flutamide
Spironolactone

11

Androgens used in HRT

Testosterone enanthate/ Testosterone cypionate

12

Flutamide (androgen receptor antagonist) indication

Metastatic prostate cancer
BPH

13

Flutamide (androgen receptor antagonist) MOA

Competitive inhibitor of DHT and T binding to receptor

14

Flutamide (androgen receptor antagonist) Side Effects

Hepatotoxicity**
Hematopoietic disorders*
Diarrhea
Nausea
Rash
Hot flashes

15

Flutamide (androgen receptor antagonist) Contraindication

Severe hepatic impairment

16

Which is the best for the treatment of prostate cancer?
A. Leuprolide
B. DES
C. Flutamide

Flutamide

17

Spironolactone (Androgen receptor antagonist) Indications

Hirsutism
Hypertension
Acne
Edema (CHF)
Cirrhosis /nephrotic syndrome
Hypokalemia

18

Spironolactone (Androgen receptor antagonist) MOA

Competitive inhibition of DHT and T binding to receptor

19

Spironolactone (Androgen receptor antagonist) Side Effects

Gastrointestinal hemorrhage
Hyperkalemic metabolic acidosis*
Agranulocytosis
SLE
Gynecomastia
Dyspepsia
Lethargy
Abnormal menstruation
Impotence
Rash

20

Spironolactone (Androgen receptor antagonist) Contraindications

Anuria
Hyperkalemia
Acute renal insufficiency

21

Spironolactone (Androgen receptor antagonist) Therapeutic consideration

An aldosterone receptor antagonist and also an androgen receptor antagonist

22

Inhibitors of Peripheral Testosterone Conversion to DHT

Finasteride

23

Finasteride (inhibitor of Peripheral Testosterone Conversion to DHT) Indication

BPH
Androgenic alopecia

24

Finasteride (inhibitor of Peripheral Testosterone Conversion to DHT) MOA

Selective inhibition of type II 5-a reductase (converts T to DHT in prostate, liver, skin)

25

Finasteride (inhibitor of Peripheral Testosterone Conversion to DHT) side effects

Breast tenderness
Decreased libido
Erectile dysfunction
Ejaculatory disorder

26

Finasteride (inhibitor of Peripheral Testosterone Conversion to DHT) Contraindication

Pregnancy
Women

27

Finasteride (inhibitor of Peripheral Testosterone Conversion to DHT) therapeutic consideration

Improves urine flow
Alternative to tranurethral resection of prostate (TURP)
25% reduction of prostate size
Most effective on large prostates