Antiparasitics

Question 0

Treat Trympanosoma brucei

Answer 0

Pentamidine, Suramin, Melarsaprol, Eflornithine, Nifurtimox

Question 1

Pentamidine mechanism

Answer 1

Binds DNA minor groove, mitochondrial as well as nuclear genome replication is affected

Question 2

Mechanism of Suramin

Answer 2

Unknown but highly toxic

Question 3

Mechanism of Melarsaprol

Answer 3

Made of arsenic, crosses BBB so will treat stage 2 T. brucei infection. Super. Toxic.

Question 4

Mechanism of Eflornithine

Answer 4

Ornithine decarboxylase inhibitor. Crosses BBB so treats stage 2 T. Brucei

Question 5

Nifurtimox mechanism

Answer 5

Oxidative stress, impairment of membrane potential

Question 6

T. Cruzi infection treatment

Answer 6

Nifurtimox and eflornithine

Question 7

Sodium stibogluconate and meglumine antimoniate mechanism

Answer 7

Target glycolysis and fatty acid beta oxidation

Question 8

Used to treat leishmania

Answer 8

Sodium stibogluconate and meglumine antimoniate and Miltefosine

Question 9

Miltefosine mechanism

Answer 9

Unknown

Question 10

Sulfadiazine/Pyrimethamine mechanism

Answer 10

Folate synthesis inhibitor, don’t use in pregnancy.

Question 11

Spiramycin mechanism

Answer 11

Macrolide that should be usedin appropriate pregnancy situations

Question 12

Used to treat toxoplasmosis

Answer 12

Sulfadiazine/Pyrimethamine and Spiramycin

Question 13

Albendazole mechanism

Answer 13

microtubule inhibotr

Question 14

Used to treat taenia solium, echinococcus granluosis, and toxocara cati

Answer 14

Albendazole