Antiparasitics Flashcards Preview

Pharma > Antiparasitics > Flashcards

Flashcards in Antiparasitics Deck (17)
1

albendazole

benzimidazoles:
antihelminthics:

NEUROCYSTICERCOSIS
INTESTINAL HELMINTHS (s. STERCORALIS

2

mebendazole

benzimidazoles:
antihelminthics:

INTESTINAL HELMINTHS

3

ivermectin

benzimidazoles:
antihelminthics:

STRONGYLOIDES
FILARIAE

4

praziquantel

benzimidazoles:
antihelminthics:
CESTODES
TREMATODES

5

artemether-lumefantrine

anti-malarials

6

atovaquone-proguanil

anti-malarials

7

chloroquine

anti-malarials:

8

mefloquine

anti-malarials

PROPHYLAXIS NOT TREATMENT

9

metronidazole

other anti-protozoal

Protozoa living in anaerobic environment

Interacts with DNA and other cellular constituents

ENTAMOEBA
GIARDIA

10

nitazoxanide

other anti-protozoal

Initial use: Cestodes

Antiprotozoal activity
- Anaerobic protozoa and bacteria
- Trichomonoas vaginalis, E. histolyticsa, C. perfrigens

Cryptosporidium parvum: only agent

Giardia lamblia (metronidazole resistant organism

11

Quinine sulfate

Anti-malarial

Oral treatment

Combination with tetracycline and doxycycline

Effective against all species

Toxicity high:
- Cinchonism (tinnitus, decreased hearing, headache)
- N/V
- Dysphoria
- Visual disturbances
Reversible

12

Quinidine

IV form of oral quinine

Adverse reaction:
- Prolong QT interval leads to arrhythmias

13

Malarone

Antimalarial

TREATMENT AND PROPHYLAXIS

Use for CQ resistant

Adverse reactions
- Abdominal pain
- N/V
- Headache

Active against hypnozoite stage

14

Primaquine

Antimalarial

Eradicates hypnozoites
prevents relapse

Interferes with mito function

Do not use in G6PD due to over oxidative stress
- Leads to hemolysis

15

Artemesinins

Antimalarial

New drug with short half life (T1/2)

16

Co-artemether

Drug of choice for self-treatment of malaria

ARTEMETHER-LUMEFANTRINE

TREATMENT

17

Paromomycin

Aminosidine
Intestinal protozoan

Lumenal agent for E. histiolytica cysts

Poorly absorbed, high conc. in intestine

Adverse reactions:
- Ototoxicity
- nephrotoxicity