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Flashcards in Adrenal Deck (19)
1

cortisol

glucocorticoids

2

dexamethasone

glucocorticoids

Oral, Injectable, Topical

3

prednisolone

glucocorticoids

Ratio of GC to MC is 5:.3

ORAL, Injectable

4

fludrocortisone

mineralocorticoids:

ORAL

5

spironolactone

mineralocorticoid antagonists:

Treats primary aldosteronism

Androgen antagonist also

6

eplerenone

mineralocorticoid antagonists:

No anti-androgen activity as seen in spironolactone

7

aminoglutethimide

synthesis inhibitors

Inhibit conversion of cholesterol to pregenenolone

Treat Cushing Syndrome

8

metyrapone

synthesis inhibitors

Treat Cushing Syndrome

inhibits

9

ketoconazole

synthesis inhibitors

Treat Cushing Syndrome

10

What are the main stimulators of mineralcorticoid production?

Increased K, Ang II, ACTH

Increase Aldosterone production from zona glomerulosa

11

What is the common progenitor to glucocorticoids, androgens, and mineralcorticoids?

Pregnenolone

12

What are the main stimulators of glucocorticoid production?

ACTH

Produces cortisol from zona fasciulata, reticularis

13

What is a result of increased ACTH levels?

Adrenal hyperplasia

Adrenal hypoplasia caused by decreased ACTH levels

14

What are the target tissues and actions of glucocorticoids?

Many tissues

Effect:
- Carb, protein, lipid metabolisms to increase blood glucose

Decrease glucose utilization

INHIBIT the IMMUNE SYSTEM and INFLAMMATORY RESPONSE

15

What is the main action of mineralcorticoids?

Aldosterone

Kidney is main target

Affects water and electrolyte balance
- Increase Na reabsorption
- Increase K excretion
- Increase H excretion

Loss is an acute and life threatening condition

16

What are some uses of GC in non-adrenal disorders?

Speed up lung maturation prior to birth

Suppress immune system for organ transplant

Treat childhood acute lymphoblastic leukemia (w/methotrexate)

Suppress immune system for symptomatic treatment of inflammatory/immune disorders

17

What are side effects of GC use?

Few if topically or administered less than 2 weeks

If continued use that adds up to 100 mg
- Hyperglycemia, glycosuria
- Increased protein breakdown
- Increased risk of infection
- Myopathy
- Osteroporosis
- Behavioral changes
- Cataracts
- ulcers
- Sodium/fluid retention
- Growth retardation in children
- Suppress HPA axis

18

What occurs in congenital adrenal hyperplasia 1?

21B hydroxylase BROKEN

Everything shifted from cholesterol to ANDROGENS

19

What is the cause of CAH-2?

11B hydroxylase knocked out but stil same effect as CAH-1

However, now have some MC function due to 11-deoxycorticosterone