antiphospholipid syndrome

Question 1

APTT in antiphospholipid syndrome

Answer 1

prolonged !!

• due to ex-vivo reaction of lupus anticoag autoantibodies with phospholids in coag cascade

Question 2

antibodies in antiphospholipid syndrome

Answer 2

anticardiolipin antibodies

anti-beta2 glycoprotein
lupus anticoagulant

Question 3

how are platelets affected in antiphospholipid syndrome

Answer 3

thrombocytopenia !!

Question 4

criteria for antiphospholipid syndrome diagnosis

Answer 4

clinical criteria (at least one)
- >= 1 thrombosis episode
- pregnancy morbidity = 3 or more spontanous abortions or fetal loss / placental insufficiency

lab criteria (at least one met on >=2 occasions at least 12weeks apart)
- anticardiolipin antibioties
(or any of the others)

Question 5

management of antiphospholipid syndrome

Answer 5

primary thromboprophylaxis;
low dose aspirin
- LMWH in high risk - pregnant

secondary thromboprophylaxis
lifelong warfarin, INR 2-3

Question 6

antiphospholipid syndrome maangement in pregnant / planning to be

Answer 6

low dose aspirin plus LMWH