SLE

Question 1

what type of hypersensitivity reaction is SLE

Answer 1

type 3 –> immune complex mediated

Question 2

most common cardiac manifesstation of SLE

Answer 2

pericarditis

also myocarditis

Question 3

SLE antibodies

Answer 3

99% ANA positive - but low specificity

highly specific
- anti-dsDNA
- anti-smith

Question 4

SLE blood count findings

Answer 4

anaemia - of chronic disease or haemolytic

lymphopenia

thrombocytopenia - due to immune mediated destructions

Question 5

disease monitoring in SLE

Answer 5

inflam markers
- ESR generally used
- CRP normal in active disease - if raised think infection

complement levels = low if active disease

anti-dsDNA antibodies - but not present in all patients

Question 6

complement levels in SLE

Answer 6

(C3, C4)

low during active disease !
-> formation of complexes leads to consumption of complement

Question 7

SLE management

Answer 7

hydroxychloroquine !!!

• NSAIDs
• sun-block

if organ involement - consider prednisolone, cyclophosphamide