systemic sclerosis

Question 1

limited cutaneous systemic sclerosis presentation

Answer 1

CREST
- calcinosis
- raynauds
- oEsophageal dysmotility
- Sclerodactyly
- Telangiectasia

scleroderma affects face + distal limbs predominately

Question 2

limited cutaneous systemic sclerosis antibodies

Answer 2

anti-centromere

Question 3

how does limited cutaneous systemic sclerosis typically first present

Answer 3

with raynauds

Question 4

diffuse cutaneous systemic sclerosis presentation

Answer 4

resp involvement - interstitial disease, pulmonary hypertension

renal disease

scleroderma affects TRUNK + PROXIMAL limbs predominately

Question 5

diffuse cutaneous systemic sclerosis complications + mx of these

Answer 5

cx = renal disease + hypertension

renal disease -> start of ACEi = captopril

poor prognosis

Question 6

antibodies in systemic sclerosis

Answer 6

ANA in 90%
RF in 30%

diffuse = anti-scl-70

limited cutaneous = anti-centromere