Antiplatelet Drugs and Thrombolytics Flashcards Preview

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Flashcards in Antiplatelet Drugs and Thrombolytics Deck (20):
1

What are non selective COX inhibitors?

aspirins and NSAIDS

2

What are selective COX2 inhibitors?

Celecoxib and Celebrex

3

What are COX3 inhibitors?

Acetaminophen (Tylenol)

4

What are PDE inhibitors?

dypridamole, and cilostazol

5

What are P2Y12 platelet receptor inhibitors (ADP receptor Antagonists)?

oral thienopyridines (grels)
- Clopidogrel and Prasugrel

6

What are Gp IIb/IIIa receptor antagonists?

-Synthetic peptides --> eptifibidate
- Antibodies --> abciximab

7

What are thrombolytic drugs?

streptokinase, urokinase, tPA, reteplase

8

What are fibrinolytic inhibitors?

Aminocaproic acid

9

What does inhibition of COX1 in platelets do?

prevents synthesis of Thromboxane

10

What is aspirin's MOA? what effect does it have on platelets?

- it acetylates COX-1
- has effect on platelets is 4-7 days, inactivates platelets for their lifetime essentially
-also inhibits COX2 in vascular endothelium to prevent PGI2 formation

11

What are the side effects of aspirin?

GI bleeding, hemorrhagic stroke, asthma

12

What is aspirin countraindicated?

courmarin, peptic ulcer disease, and aspirin hypersensitivity

13

Do NSAIDS have an reversible or irreversible effect on COX1/2?

reversible

14

Can you aspirins and NSAIDS are the same time?

NOOOO b/c non-selective COX inhibitors compete w/ aspirin for binding to COX.

15

What COX-2 inhibitor increases coronary heart risk?

Refacoxib -- w/drawn from market

16

When do you only use aspirin?

for antiplatelet effect

17

What does PDE do?

It converts cAMP to AMP and decreases Ca concentration w/in platelets and inhibits platelet activation and aggregation

18

What else do PDE inhibitors do besides inhibiting PDE?

activate plateley adenylate cyclase by inhibiting adenosine uptake.

19

What can dipyrdiamole do?

-potent vasodilator, can induce coronary steal in cardiac studies

20

What are side effects of dipyrdiamole?

headache, dizziness, and GI upset