Flashcards in Antiplatelet Drugs and Thrombolytics Deck (20):
What are non selective COX inhibitors?
aspirins and NSAIDS
What are selective COX2 inhibitors?
Celecoxib and Celebrex
What are COX3 inhibitors?
What are PDE inhibitors?
dypridamole, and cilostazol
What are P2Y12 platelet receptor inhibitors (ADP receptor Antagonists)?
oral thienopyridines (grels)
- Clopidogrel and Prasugrel
What are Gp IIb/IIIa receptor antagonists?
-Synthetic peptides --> eptifibidate
- Antibodies --> abciximab
What are thrombolytic drugs?
streptokinase, urokinase, tPA, reteplase
What are fibrinolytic inhibitors?
What does inhibition of COX1 in platelets do?
prevents synthesis of Thromboxane
What is aspirin's MOA? what effect does it have on platelets?
- it acetylates COX-1
- has effect on platelets is 4-7 days, inactivates platelets for their lifetime essentially
-also inhibits COX2 in vascular endothelium to prevent PGI2 formation
What are the side effects of aspirin?
GI bleeding, hemorrhagic stroke, asthma
What is aspirin countraindicated?
courmarin, peptic ulcer disease, and aspirin hypersensitivity
Do NSAIDS have an reversible or irreversible effect on COX1/2?
Can you aspirins and NSAIDS are the same time?
NOOOO b/c non-selective COX inhibitors compete w/ aspirin for binding to COX.
What COX-2 inhibitor increases coronary heart risk?
Refacoxib -- w/drawn from market
When do you only use aspirin?
for antiplatelet effect
What does PDE do?
It converts cAMP to AMP and decreases Ca concentration w/in platelets and inhibits platelet activation and aggregation
What else do PDE inhibitors do besides inhibiting PDE?
activate plateley adenylate cyclase by inhibiting adenosine uptake.
What can dipyrdiamole do?
-potent vasodilator, can induce coronary steal in cardiac studies