Cancer Drug Toxicities and MOA Flashcards Preview

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Flashcards in Cancer Drug Toxicities and MOA Deck (28):
1

Pulmonary Fibrosis

methotrexate and bleomycin

2

what can't be given w/ fludarabine

pentostatin

3

hemorrhagic cytitis

cyclophosphamide and ifosphamide

4

CV toxicity

anthracycline, arsenic, nilotinib, mitoxantrone, IFN 2 alpha beta

5

Neuropathy

vins

6

leukocytosis

ATRA and arsenic

7

hyperuricemia

bendamustine

8

infusion

mabs and bendamustine

9

birth defects

thalidomide, imatinib, hydroxurea

10

exfolative dermatitis

rituximab, ibrutimomab, metho

11

hepatic disease

dacarbazine and anthracyclines

12

TPMT genotyping

6MP and TG

13

Pregnancy contraindication

chlorambucil, dacarbazine, mechlorethamine

14

MOA for cyclophosamide

cell cycle inhibitor

15

Side effects for cyclophosamide

renal failure, hematuria, hemorrhagic cystitis

16

MOA for dacarbazine

methylating agent on )6

17

Metho MOA

DHFR inhibitor

18

Cytarabine MOA

inhibits chain elongation

19

6MP MOA

has some effects on HGPRT

20

Fludarabine MOA

ribonulceotide reductase inhibitor

21

anthracyclines MOA

topo II enzymes

22

bleomycin MOA

drug-Fe complex breaks DNA

23

hydroxyurea MOA

free radical scavenger, ribonucleotide reductase inhibitor

24

thalidomide MOA

enhances NK cell activity and peripheral neutropathy

25

IFN 2ab MOA

induces immunologic response

26

intrathecal administration = DEATH

vins

27

hypersensitivity

asparaginase, carboplatin, teniposide, tositumomab, rituximab

28

suicide and depression thoughts

IFN 2ab