Antiplatelets (clopidogrel) Flashcards Preview

Year 3 - Therapeutics > Antiplatelets (clopidogrel) > Flashcards

Flashcards in Antiplatelets (clopidogrel) Deck (7)
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1
Q

What is the method of action of clopidogrel?

A
  • Activated by CYP450 enzymes
  • Irreversibly inhibits the adenosine diphosphate receptor P2Y12 on the platelet surface from binding to ADP (signal for platelet aggregation)
  • Glycoprotein GPIIb/IIIa complex is not activated = no platelet aggregation
2
Q

What are the indications for clopidogrel?

A
  • Treatment of acute coronary syndrome
  • Prevent occlusion of coronary artery stents
  • Secondary prevention of thrombotic arterial event – for those with cardiovascular, cerebrovascular and peripheral arterial disease
  • Reduce risk of intercardiac thrombus and embolic stroke in AF
3
Q

What are the contraindications for clopidogrel?

A
  • Active bleeding
  • 7 days before elective surgery – should be stopped
  • Renal impairment
  • Hepatic impairment
4
Q

What are the side effects of clopidogrel?

A
  • Bleeding
  • GI upset – dyspepsia, abdominal pain, diarrhea
  • Thrombocytopenia
5
Q

What are the interactions with clopidogrel?

A
  • Cytochrome P450 inhibitors – reduce efficacy e.g.
  • Omeprazole
  • Ciprofloxacin
  • Erythromycin
  • Antifugals
  • SSRIs
  • Other antiplatelets i.e. aspirin
  • Anticoagulants i.e. heparin
  • NSAIDs – increased risk of bleeding
6
Q

Which organ eliminates clopidogrel?

A
  • Kidney

* Faeces

7
Q

What patient information should be given to patients on clopidogrel?

A
  • Continuation of treatment is essential

* Stopping bleeding will take longer than expected

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