Antiprotozoal and antihelminthic drugs Flashcards
(25 cards)
Amebiasis- luminal form
Diloxanide
Paromomycin
Etofamid
Iodoquinol
Amebiasis - invasive
Metronidazole ( tinidazole , ornidazole)
Amebiasis- reserve drugs
Chloroquine
Dehydroemetine
Giardiasis
Metronidazole
Nitazaxanide
Albendazole
Trichomoniasis
Metronidazole
Tinidazole
Ornidazole
Toxoplasmosis
Pyrimethamine with sulfonamides- - (sulfadiazine, cotrimoxazole) or macrolide (spiramycin)
Leishmaniasis
Visceral- sodium stibogluconate
Meglumine antimonate
Or pentamidine, amphotericin B
Cutaneous— paromomycin
Meglumine antimonate
Schistosomiasis
Metrifonate
Oxamniquine
Trypanosomiasis- american
“Chagas disease”
- Nifurtimox
African trypanosomiasis
“Sleeping sickness”
Suramin
Efornithine
Melarsoprol
Balantidiasis
Tetracycline
Metronidazole
Antimalarial drugs- 1) blood schizontocides
Quinine Quinidine Chloroquine Sulfadoxine / pyrimethamine Mefloquine Artesunate Artemether Dihydroartemisinine
Anti malarial- tissue schizontocides
Primaquine
Chemoprophylaxis of malaria- individual
Chloroquine
Mefloquine
Doxycycline
Chemoprophylaxis of malaria - social
Gametocides drugs -
Chloroquine
Primaquine
Quinocide
Intestinal nematodes
Albendazole Mebendazole Pyrantel Levamisole Thiabendazole Piperazine Pirviny paniya
Extra-intestinal nematodes
Mebendazole
Ivermectin
Diethylcarbamazine
Cestodiasis
Praziquantel
Niclosamide
Albendazole
Mebendazole
- clonorchiasis
- opistorhosis
- schistosomiasis
- paragonimiasis
Praziquantel
Fascioliasis
Triclabendazole
Bithionol
Trematodiasis
Together with drugs for treatment of extra-intestinal nematodes constitute group of drugs for treatment of helminthic infections
MAO: piperazine and ivermectin
Open the helminthic cl- channels –>
hyper polarization and relaxation of parasite muscles
MOA: praziquantel
Influx of ca2+ ions —>
Spams of the muscle of parasite
MOA: pyrantel pamoate levomisole
Hyper stimulation of the para’s nicotinic receptor —> paralysis of helminth muscle
