Brainscape's Knowledge GenomeTM


Top Flashcards (Certified)
All Flashcards

Pharmacology > Antipsychotics > Flashcards

Antipsychotics Flashcards

1
Q

Antipsychotic with the largest effect on EEG

A

Clozapine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Antipsychotic with the lowest effect on EEGs

A

Quetiapine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Receptor thought to mediate the erectile dysfunction side effects of antipsychotics

A

Cholinergic receptor antagonism

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Causes of sexual dysfunction in antipsychotic use

A

Due to elevated prolactin levels

Anticholinergic and antiadrenergic effects independent of prolactin levels

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Antipsychotics with greatest prolactin elevation

A

Risperidone/paliperidone

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Antipsychotics with the greatest impact on sexual function

A

Risperidone/paliperidone

Haloperidol

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Percentage of patients taking haloperidol and risperidone/paliperidone who report sexual dysfunction

A

70%

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Antipsychotics with lowest sexual dysfunction effects

A

Aripiprazole
Asenapine
Lurasidone

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Proposed mechanisms of action of antipsychotic related weight gain

A 
5HT2A and 5HT2C antagonism
D2 and D3 antagonism
H1 antagonism
M3 antagonism
Hyperprolactinaemia
Increased serum leptin leading to leptin desensitisation
Ghrelin
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Antipsychotics with high risk of weight gain

A

Clozapine

Olanzapine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Antipsychotics with moderate risk of weight gain

A

Chlorpromazine
Quetiapine
Risperidone
Paliperidone

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Antipsychotics with low risk of weight gain

A 
Amisulpride
Asenapine
Aripiprazole
Haloperidol
Sulpride
Lurasidone
Ziprasidone
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Antipsychotic which has been seen to cause weight loss when used with clozapine or olanzapine

A

Aripiprazole

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Antipsychotic associated weight gain liraglutide can be used for

A

Clozapine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Typical antipsychotic felt to be most effective in depot form - possibly with higher side effects

A

Zuclopenthixol

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Atypical antipsychotics available in depot form

A

Risperidone - as risperdal consta or paliperidone
Olanzapine
Aripiprazole

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

Requirement for test dosing with depot antipsychotics

A

Always required for first generation antipsychotics

Should be considered for second generation antipsychotics if it is not clear if an oral dose has been taken

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

Base of second generation antipsychotic depot medications which is not known to be allergenic

A

Aqeous

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

Time during depot dosing when patients may be at highest risk of a relapse

A

Immediately after a depot dose

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

Time after withdrawing an antipsychotic depot when relapse occurs in trails

A

3-6 months after stopping

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

Site into which olanzapine depot must be injected

A

Gluteal

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

Cause of post injection syndrome in giving antipsychotic depots

A

Accidental entry into a blood vessel on administration

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
23
Q

Features of post injection syndrome

A 
Sedation
Confusion
Dizziness
Agitation/aggression
EPSEs
HTN
Convulsion
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
24
Q

Typical antipsychotics

A 
Chlorpromazine
Flupenthixol
Zuclopenthixol
Perphenazine
Sulpride
Haloperidol
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
25
Atypical antipsychotics
``` Clozapine Risperidone Olanzapine Quetiapine Ziprasidone Amisulpride Aripiprazole ```
26
Active metabolite of thioridazine
Mesoridazine
27
Base of first generation antipsychotic medications
Coconut oil or sesame oil
28
Time after injection when depot flupentixol reaches peak levels
3-7 days
29
Time after injection when depot fluphenazine reaches peak levels
24 hours
30
Time after injection when depot haloperidol reaches peak levels
7 days
31
Time after injection when depot zuclopenthixol reaches peak levels
7 days
32
Active metabolite of risperidone
9-hydroxyrisperidone
33
Active metabolite of risperidone
Paliperidone
34
Active metabolite of aripiprazole
Dihydroaripiprazole
35
Depot antipsychotics which require oral cover after the first dose is administered
Risperidone | Pipotiazine
36
Atypical antipsychotic with the shortest half life
Qetiapine
37
Antipsychotics with a high risk of raised prolactin levels
``` All typical antipsychotics Risperidone Sulpride Amisulpride Paliperidone ```
38
Antipsychotics with a low risk of raised prolactin
Lurasidone Olanzapine Ziprasidone
39
Antipsychotics with a very low risk of prolactin elevation/prolactin sparing
Clozapine Aripiprazole Asenapine Quetiapine
40
Advised duration of treatment with antipsychotics for schizophrenia
1-2 years
41
Incidence of post injection syndrome
<0.1%
42
Time frame within which post injection syndrome nearly always occurs
Within 1 hour of injection
43
Hours for which a patient must be supervised after olanzapine depot injection
3 hours
44
Antipsychotic associated with post injection syndrome
Olanzapine
45
Antipsychotic which can be given at highest doses in depot form
Flupentixol
46
Benefits to giving flupentixol in high doses compared to standard doses
Likely none
47
Depot form of olanzapine
Olanzapine pamoate/emboate
48
Antipsychotics most associated with postural hypotension
``` Risperidone Clozapine Olanzapine Paliperidone Quetiapine Ziprasidone ```
49
Antipsychotics to consider if postural hypotension is an issue
Amisulpride Sulpride Aripiprazole Haloperidol
50
Most sedating antipsychotic
Clozapine
51
Antipsychotic associated with pathological gambling
Aripiprazole
52
Antipsychotic which should be given twice a day specifically at high doses
Amisulpride
53
Antipsychotic which causes photosensitivity reactions
Chlorpromazine
54
Antipsychotics which have high D2/low 5HT2 activity
Typical antipsychotics - typical of haloperidol
55
Antipsychotics which have high D2/high 5HT2 activity
Atypical antipsychotics - olanzapine, risperidone, loxapine
56
Antipsychotic which has low D2/high 5HT2 activity
Clozapine
57
Antipsychotic which could be considered to have low D2/low 5HT2 activity
Quetiapine
58
Antipsychotic best tolerated to treat side effects of Parkinson's medication for patients with Parkinson's disease
Quetiapine
59
Possible pharmacological bases for hypersalivation associated with clozapine
Muscarinic M4 agonism Adrenergic alpha-2 antagonism Inhibition of the swallowing reflex
60
Timings for patients on clozapine or olanzapine to have their lipids checked
3 monthly during first year of treatment | Yearly afterwards
61
Antipsychotic associated with reduced seizure threshold
Clozapine
62
Age group where antipsychotic related weight gain is more significant
Children
63
Most effective antipsychotic for schizophrenia in patients with hyponatraemia
Clozapine
64
Antipsychotic known for being a pure D2 antagonist
Sulpride
65
Antipsychotic most likely to induce seizures
Clozapine
66
Primary factor for classifying antipsychotics into first and second generation
Propensity for extrapyramidal side effects
67
Time frame within which the greatest improvement is seen after starting an antipsychotic
Within the first week
68
Most common cause of secondary amenorrhoea in patients on antipsychotics
Pregnancy
69
Antipsychotic associated with a contact dermatitis
Chlorpromazine
70
First generation antipsychotic also used as an antiemetic in palliative care
Chlorpromazine
71
Receptor chlorpromazine acts on to make in an effective antipsychotic
Dopamine receptors
72
Antipsychotics most likely to cause orthostatic hypotension
Clozapine | Risperidone
73
Antipsychotic most likely to cause nausea and vomiting
Aripiprazole
74
Antipsychotics associated with pigment deposit in the anterior lens capsule
Chlorpromazine | Thioridazine
75
Antipsychotic with the lowest dropout rate in the CATIE study
Olanzapine

Pharmacology (34 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2025 Bold Learning Solutions. Terms and Conditions