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Pharmacology > Half lives > Flashcards

Half lives Flashcards

1
Q

Half life definition

A

Time for concentration of a drug to fall to half its value

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2
Q

Number of half lives taken to reach steady state (without loading dose)

A

4-5

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3
Q

Number of half lives taken for drug to be 97% eliminated - taken to be fully eliminated

A

5

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4
Q

Half life of diazepam

A

20-100 hours

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5
Q

Half life of aripiprazole

A

75-90 hours

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6
Q

Aripiprazole time to steady state

A

2 weeks

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7
Q

Half life of olanzapine

A

30 hours

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8
Q

Olanzapine time to steady state

A

1 week

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9
Q

Half life of risperidone

A

20 hours

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10
Q

Risperidone time to steady state

A

2-3 days (oral)

6-8 weeks (depot)

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11
Q

Half life of clozapine

A

12-16 hours

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12
Q

Clozapine time to steady state

A

2-3 days

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13
Q

Half life of amisulpride

A

12 hours

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14
Q

Amisulpride time to steady state

A

2-3 days

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15
Q

Half life of quetiapine

A

6 hours

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16
Q

Quetiapine time to steady state

A

2-3 days

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17
Q

Half life of fluoxetine

A

4-6 days

However can inhibit its own clearance so displays non-linear pharmacokinetics

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18
Q

Reason half life does not correlate with duration of action for irreversible MAIOs

A

Because new MAO enzyme needs to be synthesised for normal action to resume which takes a minimum of 5-7 days

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19
Q

Half life of venlafaxine (normal release)

A

3.5 hours

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20
Q

Half life of venlafaxine (normal release)

A

3.5 hours

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21
Q

Half life of duloxetine

A

12 hours

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22
Q

Half life of buspirone

A

2-11 hours (hence given TDS)

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23
Q

Half life of mirtazapine

A

20-40 hours

24
Q

Half life of lithium

A

18 hours initially

After chronic use 36 hours

25
Q

Lithium time to reach steady state

A

4-5 days

26
Q

Carbamazepine time to reach steady state

A

14 days

27
Q

Half life of valproate

A

9-16 hours

28
Q

Half life of carbamazepine early in treamtent

A

24 hours

29
Q

Half life of carbamazepine in prolonged treatment, once autoinduction of CYP3A4 has occured

A

8 hours

30
Q

Half life of gabapentin

A

4-9 hours

31
Q

Half life of depot haloperidol

A

3 weeks

32
Q

Half life of depot flupentixol

A

17 days

33
Q

Half life of depot duclopenthixol

A

7-20 days

34
Q

Half life of diazepam

A

20-100 hours

35
Q

Half life of clonazepam

A

18-50 hours

36
Q

Half life of chlordiazepoxide

A

5-30 hours

37
Q

Half life of nitrazepam

A

15-38 hours

38
Q

Half life of temazepam

A

8-22 hours

39
Q

Half life of lorazepam

A

10-20 hours

40
Q

Half life of alprazolam

A

10-15 hours

41
Q

Half life of oxazepam

A

6-10 hours

42
Q

Half life of zaleplon

A

1 hour

43
Q

Half life of zopiclone

A

4-5 hours

44
Q

Half life of zolpidem

A

1-4 hours

45
Q

Half life of donepezil

A

70 hours

46
Q

Half life of pregabalin

A

6 hours

47
Q

Half life of methadone

A

15-22 hours

48
Q

Half life of oral buprenorphine

A

24-42 hours

49
Q

Half life of naloxone

A

30-120 minutes

50
Q

Half life of naltrexone

A

4-6 hours

51
Q

Half life of paliperidone depot

A

25-50 days

52
Q

Half life of olanzapine depot

A

30 days

53
Q

Half life of zuclopenthixol depot

A

19 days

54
Q

Half life of haloperidol depot

A

21 days

55
Q

Half life of fluphenazine depot

A

6-9 days

Pharmacology (34 decks)

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