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NeruoMSK > Antipsychotics > Flashcards

Antipsychotics Flashcards

1
Q

Chlorpromazine

A

1st gen antipsych

**Low potency

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2
Q

Fluphenazine

A

1st gen antipsych

    • High potency
  • Long acting injectable for noncompliance
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3
Q

Thiroidazine

A

1st gen antipsych

  • *Low potency
  • causes orthostatic hypotension ++++ worse for this
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4
Q

Haloperidol

A

1st gen antipsych

  • *High potency
  • Long acting injectable for noncompliance
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5
Q

Benzotropine & Trihexyphenidyl

A

EPS Tx acute and maintenance

Anticholinergic for EPS

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6
Q

Diphenhydramine (benadryl)

A

EPS tx acute and maintenance

Antihistamine for EPS

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7
Q

Valbenazine; Deutetrabenazine

A

Tardive Dyskinesia Tx

VMAT2 inhibitors

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8
Q

Lurasidone

A

2nd gen (DA/5HT antagonist)
5HT-2A/DA antagonist
**also partial 5HT-1A agonist
*not bad for weight gain -/+

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9
Q

Risperidone

A

2nd gen (DA/5HT antagonist)
5HT-2A/DA antagonist
* Long acting injectable for noncompliance

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10
Q

Ziprasidone

A

2nd gen (DA/5HT antagonist)
5HT-2A/DA antagonist
**no weight gain really

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11
Q

Aripiprazole

A

2nd gen (DA/5HT antagonist)
DA/5HT-1A agonist
** minimal SEs
* Long acting injectable for noncompliance

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12
Q

Cariprazine

A

2nd gen (DA/5HT antagonist)
Both 5HT-2A/DA antagonist + DA/5HT-1A agonist
**not bad for weight gain +

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13
Q

Clozapine

A

2nd gen (DA/5HT antagonist)
Multi target
**Weight gain ++++
sedating
**Rare SE - Agranulocytosis (monitor WBC)
** Used for Multi-Drug resistance Dz
***Used for Psychotic with suicidal thoughts/behaviors

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14
Q

Olanzapine

A

2nd gen (DA/5HT antagonist)
Multi target
**Weight gain ++++
*** Drug Reaction Eosinophilia Systemic Symptoms (DRESS) - rare life threatening drug induced hypersensitivity. (long latency after exposure (2-8 weeks)) GIVE Dantrolene for this
* Long acting injectable for noncompliance

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15
Q

Quetiapine

A

2nd gen (DA/5HT antagonist)
Multi target
*sedating (“quiet”)

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16
Q

Pimavanserin

A

Inverse Serotonin agonist/antagonist

**for pts with parkinsons that progressed to Hallucinations!

17
Q

Dantrolene

A

Antidote for Neuroleptic Malignant Syndrome (NMS)

- closes the ryanodine receptor to stop Ca2+ which stops muscle contraction

NeruoMSK (6 decks)

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