Brainscape's Knowledge GenomeTM


Top Flashcards (Certified)
All Flashcards

Cardio > Antithrombotics Antiplatelets > Flashcards

Antithrombotics Antiplatelets Flashcards

(62 cards)

Start Studying
1
Q

Antidote of Dabigatran

A

Idarucizumab

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Non valvular Afib means

A

AF in absence of RHD,Prosthetic valve, MVrepair- ACC AHA 2011

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Exclusion criteria in RELY trial

A

Prosthetic valve or hemodynamically relevant valve disease

In ROCKET AF-Prosthetic valve Or significant MS excluded

ARISTOTLE-Moderate to Severe MS and Prosthetic valve excluded

DRA in that order

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Interaction b/w Digoxin and Amiodarone

A

Increases Digoxin levels

Reduce dose by 50%

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Interaction b/w Digoxin And Warfarin

A

Digoxin increases INR

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Food increases the bioavailability of which NOAC

A

Rivaroxaban -with food 100% and without 66%

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Half life of Alteplase

A

3-4 mts

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

The tissue plasminogen activator is

A

rTPA- Alteplase

Reteplase is nonglycosylated form of rTPA- it is known as rPA

Tenecteplase is a multipoint (3 point mutations) mutant of rTPA has longer half life

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Half life of Alteplase

A

3-4 mts

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

The tissue plasminogen activator is

A

rTPA- Alteplase

Reteplase is nonglycosylated form of rTPA- it is known as rPA

Tenecteplase is a multipoint mutant of rTPA has longer half life

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Half life of Alteplase

A

3-4 mts

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

The tissue plasminogen activator is

A

rTPA- Alteplase

Reteplase is nonglycosylated form of rTPA- it is known as rPA

Tenecteplase is a multipoint mutant of rTPA has longer half life

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

USPSTF recommends Aspirin for

A

> 50 yrs with >10% risk

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Non thienopyridine P2Y12 inhibitors

A

Ticagrelor, Cangrelor

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Dabigatran phase 3 trial was published in

A

2009

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

NOAC indicated if CHADS2 Vasc score is

A

2

If score is 1 it can be considered

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

NOAC -Efficacy wise best p value is…

Safety wise best p value is….

A

Dabigatran

Safety- Apixaban

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

4 studies on NOAC plus anti platelet

A
  1. PIONEER AF PCI- Rivoroxaban
  2. RE -DUAL PCI- Dabigatran
  3. ENTRUST AF PCI- Edoxaban
  4. AUGUSTUS-Apixaban

Last 3 ongoing studies as of 09/2017

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

Which trial showed Rivaroxaban reduced mortality post ACS

A

ATLAS ACS -2 TIMI 51

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

How to load Ticagrelor after Clopidogrel acute setting

A

180 mg
Irrespective of time and dose of Clopidogrel

If other way round loading Clopidogrel after Tica is 600mg AFTER 24 Hours of Tica

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

Interchange between Prasu and Clopidogrel in acute setting

A

Prasu 60 mg irrespective of Clopidogrel timing and dose

Clopidogrel loading 600mg AFTER 24 Hours of Prasu

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

Interchange between Prasu and Tica in acute setting

A

Tica 180 24 hours after Prasu

Prasu 60 24 hours after Tica

Same either way

ESC 2017

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
23
Q

How to switch between Clop,Prasu,&;Tica in chronic setting

A

After Tica 24 hrs after loading dose load both clop and Pras

No loading for Tica

Between Clop and Pras . No loading dose . Normal dose after 24 hrs

In acute setting always give loading dose

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
24
Q

Use of NOAC is discouraged in which VHD

A

Moderate-Severe Mitral stenosis

ESC 2017

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
25
Use of NOAC in AS/AR/MR ESC 2017
IIa recommendation
26
GUSTO moderate bleeding criteria
Any bleeding which needs blood transfusions Severe is IC Bleed & Any bleed which needs intervention For hemodynamic compromise All others -Mild
27
Clopidogrel is the default antiplatelet post PCI only in
Stable CAD & Along with Oral anticoagulation ESC 2017
28
Duration of DAPT in stable CAD
DES And BMS - both 1-6 monthsw ESC2017
29
Duration of DAPT after ACS
12 months 6 months- If bleeding risk high >12 months-if ischemic Risk high ESC2017
30
Duration of DAPT is not decided by stent type::This conclusion was by
I ESC2017
31
Duration of triple therapy after ACS if required is for
Only 6 months ESC 2017
32
After Stenting (DES/BMS) Surgery is permitted after
1 month- If Aspirin can be continued If both has to be stopped, bridge with Cangrelor, Tirofiban or Eptifibatide ESC 2017
33
Post CABG antiplatelets(after ACS)
DAPT for 1year But role of DAPT after CABG for stable CAD is uncertain ESC 2017
34
Triple therapy increases bleeding risk by
2-3 Times
35
Cangrelor half life and duration of action
10 mts- half life | 2 hours- platelet function becomes normal
36
Tenecteplase is administered over
5 seconds
37
Position of Bivalirudin after ESC 2017
Downgraded from Class I To II a
38
Role of RBBB and LBBB in urgent CAG -ESC 2017
Equal
39
The ESC 2017 change in paradigm on DAPT
“DAPT is a regimen to treat the patient and not the previously implemented stent” Ie individual patient’s ischemic risk versus bleeding risk
40
ESC 2017 recommendation on DAPT
12 months irrespective of revasc strategy 6 mon- If bleeding risk high More than 12 mon - consider if no bleeding compln in 12 months
41
Addition of DAPT to OAC increase bleeding risk by
2-3 fold ESC 2017 Duration of DAPT maximum should be 6 months Use only Clopidogrel
42
Default P2Y12 in stable CAD treated with PCI
Clopidogrel For ACS
43
Definition of HTN in CHADS2 VASc
BP >140/90 on at least two occasions
44
Definition of stroke in CHADS2 VASc score
Includes any thromboembolism also
45
Definition of Vascular disease in CHADS2 VASc score
MI, PAD, Aortic plaque
46
Varying coupling interval in VPCs indicate
Parasystole( not an extrasystole) Two independent pacemakers functioning asynchronously . Can happen with extra systole also If coupling interval is constant it means it’s a VPC arising from the same focus
47
Anticoagulant effect of Apixaban lasts for........after last dose
24 hours - ie about 2 half lives | No established way to reverse the effect
48
When will you reduce the dose of apixaban to 2.5 mg BD
1. Wt less than 60kg 2. Creatinine-1.5 3. Age-80
49
DAPT+ OAC increases bleeding complications by ......... times
2-3 Times compared to DAPT alone
50
Duration of triple therapy if indicated
Max 6 months or till Hospital discharge
51
Default P2Y12 in PCI
Stable CAD- Clopidogrel ACS- Tica or Prasu Triple therapy- Clopidogrel ESC 2017
52
Risk factors for increased bleeding with DAPT
Prior h/o bleeding | Female ,Elderly,CRF
53
2015 PEGASUS trial is about
Ticagrelor in pts with prior MI- long term use
54
Studies which showed one month DAPT can be used in DES treated patients with better results than BMS
LEADERS FREE ZEUS
55
Risk scoring tool for DAPT bleeding risk
PRECISE DAPT 2017
56
Direct acting P2Y12 inhibitors
Ticagrelor And Cangrelor
57
Difference in changing from Prasugrel to Ticagrelor in Early and Late (>30days) phase
In early phase- After 24 hrs of last Prasugrel- LD 180 mg Late phase- After 24 hrs of last Prasugrel - 90 mg BID- MD
58
Prasugrel should be stopped how many days before surgery Ticagrelor Clopidogrel
P-7 days Others- 5 days
59
How to change from Ticagrelor to Clopidogrel
600 mg LD-24 hrs after last T dose Both in Early and Late phase
60
In the late ( more than 30 days after index event)clop/ prasu/ Tica switch :-loading dose is used only when
1. Tica changed to Clopidogrel or 2. Tica changed to Prasugrel 24 hrs from last Tica dose 600mg and 60 mg respectively All other late switching is easy- Maintanence dose after 24 hrs
61
Early phase (30 days or less from index event)antiplatelet switching
For all it’s same. Give loading dose after 24 hours
62
Triple therapy strategy used in RE DUAL PCI trial
BMS- After 1 month Aspirin was stopped DES-After 3 months Aspirin was stopped

Cardio (36 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2025 Bold Learning Solutions. Terms and Conditions