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Flashcards in Antiviral Handout Deck (6)
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1

why is selective toxicity more difficult for viruses v. bacteria?

- viruses use host cell machinery = fewer difference b/w host and virus cell parts = fewer targets to go after

2

difficulties in developing antiviral drugs

- wide spectrum of heterogeneous agents
- few viral proteins and fewer host proteins have turned out to be useful drug targets
- antivirals usually effective against only a few viruses = difference from antibacterials

3

3 indications for acyclovir

- mucocutaneous herpetic lesions
- genital herpes lesions
- prophylaxis in AIDS and other IC pts

4

2 blood-related adverse effects of ganciclovir

- leukopenia = low leukocytes in blood
- thrombocytopenia = low platelets in blood

5

what can you monitor to determine duration of foscarnet action?

- check creatinine, BUN, and ions weekly if therapy is used

6

major toxicity of zanamavir and who should it NOT be prescribed to

- major toxicity = bronchospasm and decline in respiratory function
- so don't give to pts w/ an airway disease i.e. asthma, COPD