Antivirales para HV Flashcards

(13 cards)

1
Q

Farm para HBV

A

IFN alfa
PegIFN alfa 2a

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2
Q

MoA de IFN alfa

A

Indice expreción MHC-I
Activa NK y Mø
Inh síntesis de prot vir
Degrada RNA viral

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3
Q

Indicas de IFN alfa

A

HBV crónica activa (monoterapia)

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4
Q

¿Cuando es util el IFN alfa?

A

Cuando hay buena función hep

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5
Q

EA de IFN alfa

A

Sx gripales
Depresión
Mielosupresión
Autoinm
Riesgo en embarazadas

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6
Q

MoA de pegIFN alfa 2a

A

Eleva lnfc. T CD8 y Mø

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7
Q

Espectro de pefIFN alfa 2a

A

HBV
HCV

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8
Q

Indicas de pegIFN alfa 2a

A

HCV crónica (tmb 2b)
HBV crónica

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9
Q

EA de pegIFN alfa 2a

A

Neuropsi
Autoinm
Isq mortales

Fatiga
Cefalea
Fiebre
Anemia
Neutropenia
Artralgia

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10
Q

MoA de ribavirina

A

Inh síntesis de guanina
Mutagénico viral

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11
Q

Idicas de ribavirina

A

HCV crónica refractaria
Virus hemorrágicos
VSR

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12
Q

EA de ribavirina

A

Anemia hemolítica
Hemólisis
Teratogénico
Nausea
Mielosupresión

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13
Q

EA de ribavirina por vía inha

A

Apnea
Neumotorax
Paro card

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