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SEM-IV Terapéutica Farmacológica > Diabetes > Flashcards

Diabetes Flashcards

(57 cards)

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1
Q

Biguanidas

A

Metformina

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2
Q

MoA de biguanidas

A

Inh gluconeogen hep
↑cap periférica de glu
↑sensibilidad insulina

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3
Q

Indicas de biguanidas

A

1º DM2
Px sobrepeso u obesidad

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4
Q

EA de biguanidas

A

Gastroint
↓ absorción v. B12
Acidosis láctica

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5
Q

Contraindicas de biguanidas

A

Filtrado glo <30 mL/min

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6
Q

Tiazolidinedionas

A

Pioglitazona
Rosiglitazon

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7
Q

MoA de tiazolidinedionas

A

Ago de R nuc. PPAR-gamma
- Aumenta sens de insulina en musc, grasa e higado (GLUT4)

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8
Q

Indicas de tiazolidinedionas

A

DM2 con resist a insul

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9
Q

Con que se combinan las tiazolidinedionas

A

Metformina

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10
Q

EA de tiazolidinedionas

A

↑ peso
Retención de liq→IC
Fracturas (>mujeres)
Pio: Ca vesical

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11
Q

Contraindicas de tiazolidinedionas

A

IC congestiva

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12
Q

Sulfonilureas

A

Glibenclamida
Glipizida
Glimepiri

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13
Q

MoA de sulfonilureas

A

Lib de insulina al bloq ca K en c. beta

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14
Q

Indicas de sulfonilureas

A

DM2 con reserva pancreática funcional
Control gli (adm regular)

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15
Q

EA de sulfonilureas

A

Hipoglucemia (riesgo alto)
Aumento de peso
Reac alérgicas cruzadas con sulfas

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16
Q

Contraindicas de sulfonilureas

A

Riesgo de hipoglu
- Viejitos
- Insuf renal

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17
Q

Glinidas

A

Repaglinida
Nateglinid

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18
Q

Moa de glinidas

A

Lib rápida de insulina

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19
Q

Indicas de glinidas

A

Comida irregulares
Hipoglu frec
Alt de sulfonilureas
DM2 control gli postprandial

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20
Q

Adm de glinidas

A

Antes de comer

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21
Q

EA de glinidas

A

Hipoglucemia
Aumento de peso
Gastrointestinales
Prurito

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22
Q

Vida media de glinidas

A

Corta
1 hrs

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23
Q

Eliminació de glinidas

24
Q

Acción de glinidas

Study These Flashcards
A

Rápido
Menos riesgo de hipoglu que sulfo

25
Incretínicos – Análogos de GLP
Vidaglutida Exenatida Liraglutida Semaglutid
26
MoA de incretínicos
Ago de R GLP-1 - ↑ secreción de insul glu-dep - ↓ glucagon - ↓ Realentizan vaciamiento gástrico
27
Indicas de incretínicos
DM2 con obesidad
28
Adm de incretínicos
Subcutáneo
29
EA de incretínicos
Nauseas Vómito Pancreatitis Pérdida de peso
30
Uso de incretínicos
NO se usan solos
31
Inh de DPP-4
Sitagliptina Saxagliptina
32
MoA de inh de DPP-4
Bloq en degradación de GLP-1 - ↑ incretininas endógenas
33
Indicas de inh de DPP-4
DM2
34
Adm de inh de DPP-4
Orales Combinados con otra cosa
35
EA de inh de DPP-4
Pancreatitis Infecc resp Cefalea Cardiovasc (Saxa)
36
Inh de α-glucosidasa
Acarbosa Miglito
37
MoA de inh de α-glucosidasa
Inh enz en borde de cepillo int → retrasa absorción de carbs
38
EA de inh de α-glucosidasa
Flatulencia Distención ab Diarrea
39
Importante de corrección de hipoglu con inh de α-glucosidasa
Adm glucosa porque sacarosa esta bloq
40
Inh de SGLT-2
Canagliflozina Dapagliflozina Empagliflozina
41
MoA de inh de SGLT-2
Inh co-transp Na-Glu tipo 2 en TP (glucosuria)
42
Indicas de inh de SGLT-2
DM2 con - ERC - riesgo cardiovascular
43
Adm de inh de SGLT-2
Oral
44
EA de inh de SGLT-2
Infecc uri y genitales micóticas Hipotensión por diuresis Cetoacidosis euglu
45
Inh de SGLT-2 útiles en IC o ERC
Dapagliflozina Empagliflozina
46
MoA de insulinas
Activan R de insulina - Estimula cap de glu - Inh gluconeogénesis hep
47
Tipos de insulinas
Rápida Intermedia Lenta / larga duración
48
Insulinas rápidas
Lispro Aspart Glulisina
49
Insulinas intermedias
NPH
50
Insulinas lentas / larga duración
Glargina Detemir Degludec
51
Indicas de insulinas
DM1 siempre DM2 cuando fallan farm orales Cetoacidosis Estrés metabólico Hospitalización
52
EA de insulinas
Hipoglu Aumento de peso Lipodistrofia
53
Inicio, pico y duración de insulinas rápidas
Inicio: 5-15 min Pico: 1 hrs Duración: 3-4 hrs
54
Inicio, pico y duración de insulina regular
Inicio: 30 min Pico: 2-3 hrs Duración: 4-6 hrs
55
Inicio, pico y duración de insulinas intermedias
Inicio: 1-2 hrs Pico: 6-10 hrs Duración: 10-16 hrs
56
Inicio, pico y duración de insulinas lentas
Inicio: 1-4 hrs Pico: no def Duración: 24-42 hrs
57
Insulinas mixtas
Insul rápida + NPH

SEM-IV Terapéutica Farmacológica (52 decks)

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