Anxiety and Insomnia Flashcards Preview

Pharmacology > Anxiety and Insomnia > Flashcards

Flashcards in Anxiety and Insomnia Deck (26):
1

The more lipid soluble the drug...

... the faster the onset and the shorter the duration of action

2

PK of diazepam

200 h, active metabolite

3

Therapeutic use of diazepam

anxiety
panic attacks
preanesthetic
muscle relaxant
status epilepticus

4

Difference between lorazepam and diazepam

lorazepam has a shorter half life

5

Therapeutic use of lorazepam

anxiety, insomnia

6

Benzodiazepines for anxiety

alprazolam, diazepam, lorazepam

7

Benzodiazepines for insomnia

triazolam, flurazepam

8

Benzos for epilepsy and seizures

diazepam and lorazepam

9

Benzos for muscle relaxation

diazepam

10

Benzos for withdrawl

lorazepam, sometimes diazepam

11

CNS effects of benzos

decrease anxiety
hypnosis
muscle relaxation
anterograde amnesia
interfere with learning and memory
additive CNS depressant effects

12

Cautions with benzos

caution in patient with sleep anpnea or chronic lung disease

13

Metabolism of long acting benzos

phase 1 and 2, with active metabolites

14

long acting benzos

diazepam and flurazepam

15

Shorter acting benzos metabolized by phase 1 and phase 2

alprazolam, midazolam, triazolam

16

Shorter acting benzos metabolized only by phase 2

lorazepam

17

Adverse effects of benzos

drowsiness, sedation
impaired motor function
confusion, memory loss (elderly)
tolerance develops to side effects, not anti-anxiety effects

18

Rare paradoxical reaction

rage reaction

19

Contraindications of benzos

pregnancy

20

withdrawl effects of benzos

anxiety (sometimes rebound), autonomic like signs

21

benzodiazepine antagonist

flumazenil

22

Therapeutic use of flumazenil

reverse sedative effect after anesthesia
reverse benzo overdose

23

Therapeutic use of buspirone

generalized anxiety disorder

24

MOA of buspirone

not clear

25

Advantages of buspirone

no hypnosis
no rebound
minimum abuse
preg cat B

26

Disadvantages of buspirone

only generalized anxiety
takes 1 to 2 weeks to produce effect