Cancer therapy Flashcards Preview

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Flashcards in Cancer therapy Deck (15):
1

MOA of alkylating agent

binds covalently to DNA, cell-cycle non-specific, most effective against rapidly dividing cells

2

Alkylating agents

cyclophosphamide (nitrogen mustards), cisplatin (platinum compounds)

3

Antimetabolite MOA

analogs of endogenous DNA and RNA precursors.
Cell cycle specific, most effective during S phase

4

Methotrexate MOA

antimetabolite, folic acid analog

5

Types of antimetabolite

folic acid analog, pyrimidine analog, purine analog

6

MOA of anti-tumor antibiotics

1. intercalation of DNA
2. cell cycle non-specific
3. adverse reaction, CHF

7

Antitumor antibiotics

doxorubicin

8

MOA of mitotic inhibitors

interfere with microtubule formation, , block cell cycle arrest in metaphase

9

Specific mitotic inhibitors

vincristine (polymerization) and paclitaxel (depolymerization)

10

MOA of topoisomerase inhibitors

inhibiton of topoisomerases causes double strand breaks. Prevent resealing of of nicked DNA. S phase specific

11

Specific topoisomerase inhibitors

irinotecan

12

MOA of rituximab

binds CD20 antigen, for B cell lymphoma

13

MOA of trastuzumab

binds HER2 receptor

14

MOA of imatinib

inhibits BCR-Abl tyrosine kinase (philadelphia chromosome) in chronic myeloid leukemia

15

Side effects of cytotoxic chemotherapy

A. Myelosuppression
B. GI
C. Alopecia
D. Secondary tumors