Antihyperlipidemic drugs Flashcards Preview

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Flashcards in Antihyperlipidemic drugs Deck (17):
1

What is the MOA of atorvastatin

Inhibits HMG CoA reductase increasing LDL Receptors

2

Effects of atorvastatin on lipids

decrease LDL*, increase HDL

3

Side effects of atorvastatin

GI, hepatotoxicity, myopathy

4

Mechanism of Fenofibrate

Agonist at PPAR-alpha, increases LP lipase and catabolism of VLDL

5

Effects of fenofibrate on lipids

decrease VLDL, decrease TG*, increse HDL

6

Side effects of fenofibrate

GI, Myosistis (especially in combo with statins)

7

Best drug for patients with elevated triglycerides

fenofibrate

8

Mechanism of colesevelam

Bind bile acids

9

Effects of colesevelam on lipids

decrease LDL, increase HDL

10

Side effects of colesevelam

GI, mild steatorrhea

11

Mechanism of Niacin

inhibit TG lipolysis, decrease TG synthesis, increase LP lipase, decrease clearence of HDL, decrease VLDL production

12

Effect of niacin on lipids

decrease VLDL, decrease TG, decrease LDL, increase HDL

13

Side effects of niacin

flusing, itching, GI, peptic ulcer, hyperglycemia, hyperuricemia, severe hepatotoxicity

14

MOA of ezetimibe

decrease intestinal transport of cholesterol

15

Effects of ezetimibe on lipids

decrease LDL

16

Side effects of ezetimibe

diarrhea

17

Which drugs have a synergistic risk of myopathy

atorvastatin, fenofibrate