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Lizzie's Metabolism > Appetite > Flashcards

Flashcards in Appetite Deck (16):
0

Where is the appetite centre?

The arcuate nucleus in the hypothalamus

1

What do primary neurones do?

Sense metabolite levels and respond to hormones

2

What do secondary neurones do?

Synthesise input from primary neurones and co-ordinate a response via the vagus nerve.

3

What do excitatory neurones secrete?

Agouti-related peptide
Neuropeptide Y

4

What do suppressor neurones secrete?

POMC

5

What can POMC be broken down into?

Other hormones such as
-beta endorphin
-ACTH
-alpha-melanocyte stimulating hormone

6

Which hormone is released from the wall of an empty stomach and how is its release inhibited?

Ghrelin
Stopped when the stomach wall is stretched.

7

Which hormone is released from the wall of the small intestine and what does it do to appetite?

PPY
Suppresses appetite

8

Which hormone is released from adipocytes? What does it do?

Leptin
Suppresses appetite
Uncouples electron transport from ATP production so heat is produced

9

Which hormone is secreted with insulin and what does it do?

Amylin
Suppresses appetite
Slows gastric emptying
Inhibits glucagon secretion

10

List some symptoms of metabolic syndrome

Insulin resistance
Dyslipidaemia
Glucose intolerance
Hypertension
Central adiposity

11

What are the WHO criteria for metabolic disorder?

Waist:hip ratio >0.9 in men and >0.85 women
BMI above 30
Blood pressure >140/90 mmHg
Triglycerides >1.7mmol/L
HDL cholesterol 7.8mmol/L

12

What does the Developmental Origins of Health Disease suggest?

That coronary heart disease, hypertension and type 2 diabetes are associated with a low birth weight.
The experience of a foetus in utero during development somehow determines the future health of an individual.

13

What is an epigenetic trait?

A stably inherited phenotype resulting from changes in a chromosome without alterations in the DNA sequence

14

What do they think epigenetic is caused by?

May be linked to methylation of DNA at crucial points and altering the histones structure causing suppression of gene transcription targeting the promoter region of specific genes.

15

What is metabolic syndrome?

Co-occurrence in an individual of a number of risk factors for cardiovascular disease including hypertension and dyslipidaemia. Usually associated with obesity and a sedentary lifestyle.