By-products Of Metabolism Flashcards Preview

Lizzie's Metabolism > By-products Of Metabolism > Flashcards

Flashcards in By-products Of Metabolism Deck (12):
0

How are ROS produced?

When an electron in the ETC prematurely reduces an oxygen to produce O2-

1

What does superoxide dismutase do? (SOD)

Catalyses the reaction of superoxide radicals together to form hydrogen peroxide

2

Which enzyme breaks down hydrogen peroxide and what does it break it down into?

Catalase
Oxygen and water

3

How does glutathione reduce ROS

The thiol (-SH) group in cysteine can donate its H and therefore act as a reducing agent.

4

What is the oxidised form of glutathione?

Glutathione disulphide (GSSG)

5

How is glutathione disulphide converted back to glutathione?

NADPH reduces it.

6

Which two vitamins are antioxidants?

C and E

7

Which drugs in particular are strong oxidising agents?

Anti-malarials

8

What is oxidative stress?

When antioxidant levels are low

9

What can oxidative stress lead to?

Atherosclerosis
Parkinson's
Alzheimer's

10

How are ROS involved in immunity?

Neutrophils and monocytes can undergo oxidative bursts, releasing a large quantity of ROS.
This kills any surrounding bacteria or fungal cells.

11

Which enzyme produces the oxidative burst?

NADPH oxidase