ARENAVIRIDAE Flashcards
(23 cards)
Arenaviridae is sensitive to ?
- Heat
- Acidic conditions
- Detergents
- Disinfectants
This initiates the transcription of Arenaviridae.
viral RNA polymerase (L protein)
Old World Arenaviruses:
Give the natural host, geographic distribution, and human ds. of Mopeia virus
- Mastomys natalensis (natal multimammate mouse)
- Southern Africa
- Infection, no ds.
Old World Arenaviruses:
Give the natural host, geographic distribution, and human ds. of Mobala virus
- Praomys jacksoni (Jackson’s furred mouse)
- Central African Republic
- Infection, no ds.
New World Arenaviruses:
Give the natural host, geographic distribution, and human ds. of Chapare Virus
- Unknown
- Bolivian
- Hemorrhagic fever
New World Arenavirus causes what disease in South America?
Hemorrhagic fever
Arenaviridae uses ____ from host mRNA’s for priming viral transcription.
cap-snatching
New World Arenaviruses:
Give the natural host, geographic distribution, and human ds. of Junin Virus
- Calomys musculinus (Drylands vesper mouse), Calomys laucha (Small vesper mouse), Akodon azarae (Azara’s akodont or Azara’s grass mouse)
- Argentina
- Hemorrhagic fever (Argentine hemorrhagic fever)
The latin word “arena” translates to?
Sand
New World Arenaviruses:
Give the natural host, geographic distribution, and human ds. of Sabia Virus
- Unknown
- Brazil
- Hemorrhagic fever (Brazilian hemorrhagic fever)
Old World Arenaviruses:
Give the natural host, geographic distribution, and human ds. of Lassa virus.
- Mastomys natalensis (natal multimammate mouse)
- West Africa
- Hemorrhagic fever (Lassa fever)
What gives Arenaviridae the grainy (sandy) appearance?
Ribosomes
Describe the genome of Arenaviridae.
- Ambisense, segmented, single stranded RNA
The **large segment” RNA of Arenaviridae encodes?
RNA polymerase (RNA) and zinc-binding matrix protein (Z)
Old World Arenaviruses:
Give the natural host, geographic distribution, and human ds. of Ippy virus
- Arvicanthus spp. (african grass rat)
- Central African Republic
- Infection, no ds.
New World Arenaviruses:
Give the natural host, geographic distribution, and human ds. of Machupo Virus
- Calomys callosus (Large vesper mouse)
- Bolivia
- Hemorrhagic fever (Bolivian hemorrhagic fever)
Give the complications/clinical signs of New World Arenaviruses in their reservoir rodent hosts.
- Cause persistent, lifelong infections
- Longterm, shedding of large amounts of virus in urine, saliva, and feces
Old World Arenaviruses:
Give the natural host, geographic distribution, and human ds. of Lujo Virus
- Unknown
- Southern Africa
- Hemorrhagic fever (Lujo fever)
The **small segment” RNA of Arenaviridae encodes?
Nucleoprotein (N) and glycoprotein precursor (GPC)
What are the 2 major opportunities for zoonotic transmission of Lymphocytic Choriomeningitis Virus?
- In winter months, infected wild mice invade dwellings and farms → dried,
virus-laden excreta can be transmitted by aerosols or fomites - Virus can be established in laboratory mouse or hamster colonies
New World Arenaviruses:
Give the natural host, geographic distribution, and human ds. of Guanarito Virus
- Zygodontomys brevicauda (short-tailed zygodont/cane mice), Oryzomys spp. (N.A. rice rats)
- Venezuela
- Hemorrhagic fever (Venezuelan hemorrhagic fever)
Arenaviridae is pleomorphic. True or False?
True, highly pleomorphic
Old World Arenaviruses:
Give the natural host, geographic distribution, and human ds. of Lymphocytic choriomeningitis virus.
- Mus musculus (house mouse)
- Worldwide
- Grippe-like ds., meningitis, meningoencephalitis
