Arthritis - OA and RA Flashcards Preview

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Flashcards in Arthritis - OA and RA Deck (17):
1

Radiographic features of OA

Joint space narrowing, marginal osteophytes, subchondral cysts, bony sclerosis

2

Laboratory features of OA

NONE! NEGATIVE!

3

Distribution of primary OA

Knees, hips, MCP, PIP, DIP, lumbar and cervical vertebrae SPARES THE WRISTS, ANKLES, AND JAWS (unless secondary OA)

4

Players in the pathogenesis of OA

MMP, IL-1, NO, and PGE

5

Signs and symptoms of OA

Pain worse through day, minimal morning stiffness (LESS THAN 20 MINUTES, IF HOURS THINK RA), bony enlargement, crepitus

6

Risk factors for OA

AGE, female, obesity, trauma

7

Epidemiology of RA

Older age, 3x more in females, increased mortality

8

Genetic risk for RA associated with which genes?

HLA-DRB1, PTPN22

9

Pathogenesis of RA

T cell activation via HLA-DR4

10

Rheumatoid factor

IgM antibodies to the Fc portion of IgG

11

RF in RA

NONSPECIFIC - also seen in Hep C + cryoglobulinemia, cigarette smoking, aging, and chronic conditions

12

Specific marker of RA

Anti-CCP

13

Signs and symptoms of RA

Morning stiffness (AT LEAST 30 MINUTES), swelling, warmth, and erythema around joint, ulnar deviation, swan neck deformities, neck pain (atlantoaxial subluxation)

14

Joint involvement in RA onset

Begins as a few random joints usually large (knee, hip)

15

Joint involvement in RA late

Symmetric; wrist and proximal hand joint, MCP + PIP, DIP SPARING; Also: knees, hips, ankles, elbows, shoulders

16

Rheumatoid nodules

Commonly on extensor surfaces

17

Other extraarticular manifestations of RA

Dry eyes, dry mouth, respiratory and cardiac involvement, peripheral neuropathy