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Flashcards in Gout and Treatment Deck (17):
1

Diagnostic criteria for gout

Urate crystals negatively birefringent and needle shaped

2

Why males are at greater risk for gout

Higher serum urate, estrogen helps clear urate in the kidneys

3

Hereditary causes of gout

PRPP synthetase variants, HGPT deficiency

4

Drugs promoting hyperuricemia

Diuretics, organic acids, ethanol

5

Risk factor for gout kidney stones

Increased uric acid excretion, reduced urine volume, low urine pH

6

Uses of colchicine

Terminate/prevent acute gout attack by preventing neutrophil chemotaxis

7

Adverse effect of colchicine

GI disturbance (diarrhea)

8

Uses of allopurinol

Xanthine oxidase inhibitor, dissolves crystals, prevents stone formation, allopurinol for life in enzyme deficient gout

9

Contraindications of allopurinol

Interacts with 6-MP, do not give with impaired renal function, don't take with ampicillin, exfoliative dermatitis

10

Uric acid on the kidney

Freely filtered at glomerulus, reabsorbed at PCT, secreted at PCT, reabsorbed again

11

MOA of probenecid

Competes with uric acid for reabsorption

12

MOA of pegloticase

Turns urate into allantion

13

Side effects of pegloticase

Gout flares, Ab to PEG

14

Calcium pyrophosphate appearance

Blue rhomboid positive birefringent

15

Common location for pseudogout

Knee, wrist

16

Pseudogout genetics

Idiopathic, associated with ANKH on chr 5p

17

Basic calcium phosphate crystals

No birefringence, linked with OA