article Flashcards
(26 cards)
how many sources were used
190
title
the gut microbiota-brain axis in behavior and brain disorders
authors
- Livia H. Morais
- Henry L. Schreiber
- Sarkis K. Mazmanian
who published it
“Reviews”
- Nature Reviews
what does GF mean
germ-free
3 ways microbiota can influence development/function of nervous system
- modulation of immune response
- impacts on metabolism
- direct effects on neuron signaling
allostasis
process used by body to respond to psychological stress and restore homeostasis
why have neurogenerative therapies been difficult to find
- limitations of animal models
- lack of understanding of disease pathology
multiple sclerosis
autoimmune demyelinating disease characterized by degeneration of neuronal signaling throughout an individual’s lifetime
Parkinson’s disease
inability to control voluntary movements
what was transplanted into people with ASD to improve gastrointestinal inflammation and symptoms?
faecal microbiota
humanized animals
human gut bacteria transplanted into animals
microglia
innate immune cells of brain
what does the vagus nerve link
gut and brain
second brain of body
ENS (enteric) division of autonomic nervous system
what type of microbiota does this paper talk about?
bacteria
astrocytes
subtype of glial cells in CNS
- BBB formation
- interfacing w/ microglia and neruons
oligodendrocytes
brain cells that regulate development of neurons and insulate asonx
neuroplasticity
ability of nervous system to change activity by reorganizing structure and function
brain-derived neurotrophic factor
protein that has important role in neuronal survival, growth, and synaptic plasticity
y-Aminobutyric acid
main inhibitory neurotransmitter in adult brain
gut-microbiota-brain axis
network of connections involving multiple biological systems that allows bidirectional communication between gut bacteria and the brain
validity in experiment
internal, external, construct, face
what does EEC stand for
enteroendocrine cells
