Asdfg Flashcards
(22 cards)
o Dohle-like bodies are present in neutrophils
o FUNCTION: NORMAL
MAY-HEGGLIN ANOMALY
MAY-HEGGLIN ANOMALY
MUTATION:
MYH9 gene = abnormal size platelets
- reflecting bone marrow failure
- affected infants = ≤ 20,000/uL at birth
- petechiae and evidence of bleeding and frequent anomalies
CONGENITAL AMEGAKARYOCYTIC THROMBOCYTOPENIA
CONGENITAL AMEGAKARYOCYTIC THROMBOCYTOPENIA
- MUTATION: _____ gene on _____ chromosome
- Complete loss of THROMBOPOIETIN RECEPTOR function
- reduced megakaryocyte progenitors and high thrombopoietin levels
MPL gene on Chromosome 1 (1p34.1)
(Ans)FALSE:
AUTOSOMAL DOMINANT THROMBOCYTOPENIA
• MUTATION:______ gene on the short arm of chromosome______
ANKRD26
10(10p12.1)
(Ans)FALSE:
AUTOSOMAL DOMINANT THROMBOCYTOPENIA
• MUTATION:______ gene on the short arm of chromosome______
ANKRD26
10(10p12.1)
- most common infectious agent
- 0.5-1% of all birth
CYTOMEGALOVIRUS: (Ans)
lead to incomplete megakaryocyte differentiation and
resultant thrombocytopenia
(Ans)FALSE:
AUTOSOMAL DOMINANT THROMBOCYTOPENIA
- More common than THROMBOTIC THROMBOCYTOPENIC PURPURA
HEMOLYTIC UREMIC SYNDROME(Ans)
- Caused by Shigella dysenteriae serotype or enterohemorrhagic E.coli OH serotypes (0157:H7)
HUS
- HALLMARK SIGNS: Mild thrombocytopenia, mild anemia, bloody diarrhea and AKI
HUS
- Common cause of destructive thrombocytopenia
DISSEMINATED INTRAVASUCLAR COAGULATION(ans)
- Common cause of destructive thrombocytopenia
DISSEMINATED INTRAVASUCLAR COAGULATION(ans)
- Function: Normal
- Morphology: Normal
- Aggregation test: Normal
REACTIVE Thrombocytosis(Ans)
- normalize the count
- Thrombosis with IDA
TREATMENT of IDA(ans)
- Chronic myeloproliferative neoplasm, is the most common cause of thrombocytosis
ESSENTIAL THROMBOCYTHEMIA (ans)
ACUTE PHASE REACTANTS (Ans)
- APR in Thrombosis associated with inflammation
- Fibrinogen, VWF
Moschcowitz Syndrome(ans)
▪ TRIAD OF:
MAHA, Thrombocytopenia & Neurologic abnormalities
- Peaks 10-17 days after withdrawal of the offending drug or after
institution of therapy for the underlying condition
REBOUND THROMBOCYTOSIS(ans)
Moschcowitz Syndrome(ans)
▪ TRIAD OF:
MAHA, Thrombocytopenia & Neurologic abnormalities
▪ TRIAD OF: MAHA, Thrombocytopenia & Neurologic abnormalities
Moschcowitz Syndrome(ans)
REBOUND THROMBOCYTOSIS(ans)
- Peaks ______after withdrawal of the offending drug or after
institution of therapy for the underlying condition
10-17 days
