Practice

Question 1

TET2 is highly mutagenic for 3 reasons

Answer 1

• Biallelic (OFTEN HOMOZYGOUS)
• All types of myeloid disorders

Question 2

Mutated mRNA is more common in…
*

Answer 2

Primary Myelofibrosis than PV and ET

Question 3

Evaluates bone marrow fat content

Answer 3

Magnetic Resonance Imaging

Question 4

First line therapy for Polycythemia Vera in EARLY STAGES

Answer 4

Therapeutic Phlebotomy

Question 5

Only therapy with curative potential. Reserved for the minority of patients who qualify

Answer 5

Stem cell transplantation

Question 6

Essential thrombocythemia: Majority is between the ages of…

Answer 6

• 50-60 years old

Question 7

Bleeding - ET occurs most often from mucous membranes in the

Answer 7

• skin
• GIT
• Urinary
• URT

Question 8

Common symptom in Polycythemia Vera

Answer 8

Splenomegaly

Question 9

Symptoms are associated with hyperviscosity and hyperproliferation

Answer 9

Polycythemia vera

Question 10

Common clinical feature of PV

Answer 10

Pruritus

Question 11

High risk patients with PV

Answer 11

• > 60 yrs old with thrombosis

Question 12

First line therapy in PV

Answer 12

Alkylating agent HYDROXYUREA

Question 13

Least common but most aggressive form of MPN

Answer 13

Primary Myelofibrosis

Question 14

The abnormal release or leakage of PDGF from the platelet. Results in reduced platelet conc. of PDGF and increased serum PDGF

Answer 14

Myelofibrosis

Question 15

Most common constitutional symptoms of PMF

Answer 15

Fatigue