ASN QBank Pearls - Glomerular and Vascular Disorders Flashcards Preview

Nephrology Board Review Pearls > ASN QBank Pearls - Glomerular and Vascular Disorders > Flashcards

Flashcards in ASN QBank Pearls - Glomerular and Vascular Disorders Deck (71)
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1

have often been associated with increased risk for progression of diabetic
nephropathy

smoking and HTN

2

which genetic screening test is likely to detect a mutation in more than 5% of sporadic FSGS in adolescents?

mutations in NPHS2 (podocin) gene, including p.R229Q variant

3

possible kidney biopsy findings in MM nephropathy

- fractured tubular casts
- Congo red–positive glomerular and tubular deposits
- acute tubular injury/necrosis
- plasma cell infiltrates

4

amyloidosis fibril size

9 to 12 nm

5

cryoglobulinemic GN microtubule shape and size

- curved
- 25-35 nm

6

immunotactoid glomerulopathy microtubule pattern and size

- parallel arrays
- > 30 nm

7

fibrillary GN fibril pattern and size

- RANDOM
- 15-30 nm

8

lupus nephritis IG pattern

"fingerprint"

9

treatment for idiopathic MCD

- sodium and fluid restriction
- furosemide
- statins
- ACEI
- high-dose prednisone daily or on alternate days

10

spontaneous remission rate of nephrotic syndrome in iMCD

1/3, but may take up to 2 years or more

11

treatment of steroid-resistant FSGS

cyclosporine A often in combination with low-dose prednisone

12

lesion associated with highest response rate to treatment with steroids and 
has the BEST prognosis in nephrotic patients with FSGS

tip lesion

13

has not been shown to be effective treatment in patients with idiopathic membranous glomerulonephritis (iMGN)

prednisone alone

14

multiple myeloma with acute cast nephropathy clues

- very low anion gap
- hypercalcemia
- anemia
- presence of trace urine protein by dipstick
- elevated UPC on direct measurement
- protein electrophoresis shows IgG kappa paraprotein

15

HIVAN

collapsing FSGS

16

HIVAN bp

rarely hypertensive

17

hepatitis B–induced membranous GN is usually associated with

hepatitis BeAg immune complexes in the subEPIthelial space

18

hepatitis BsAg-induced MPGN is usually associated with

subENDOthelial deposits due to the different sizes of molecules

19

hepatitis C leads to what type of cryoglobulinemia

type 2

20

hepatitis C leads to what type of MPGN

type 1 MPGN

21

cryoglobulins activate which complement pathway

classical complement pathway

22

HIV directly infects renal tissue including the

- podocytes
- mesangial cells, and
- renal tubular cells

23

associated renal lesion;
- hepatitis A

postinfectious GN (PIGN)

24

associated renal lesion;
- HIV

collapsing FSGS

25

associated renal lesion;
- hepatitis C

MPGN

26

associated renal lesion;
- hepatitis B

membranous GN

27

HIVAN or collapsing FSGS is due to

active viral replication in the podocyte --> podocytes change to proliferative macrophages

28

treatment that may lead to an improvement in renal function and nephrotic syndrome in HIVAN

- HAART
- ACEI or ARB, and
- steroids

29

HIVAN predominantly diagnosed in patients of what race

black

30

HIVAN predominantly affects what sex

males > females