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Associations Flashcards

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1
Q

type 1 diabetes mellitus Is associated with Which HLA Antigen

A

HLA-DR4

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2
Q

C1 inhibitor (C1-INH) deficiency predisposes to what?

A

hereditary angioedema

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3
Q

Deficiency in what compliments predisposes to immune complex disease e.g. SLE, Henoch-Schonlein Purpura

A

C1q, C1rs, C2, C4 deficiency

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4
Q

HLA-DR4 Is associated with which conditions?

A

type 1 diabetes mellitus
rheumatoid arthritis

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5
Q

HLA - B51 is associated with which disease?

A

Behcet’s Disease

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6
Q

What is the most abundant immunoglobulin isotype in blood serum?

A

IgG

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7
Q

What is the function of Interleukin 3?

A

Stimulates differentiation and proliferation of myeloid progenitor cells

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8
Q

rheumatoid arthritis is associated with which HLA antigen

A

HLA-DR4

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9
Q

What condition is associated with HLA A3?

A

Haemochromatosis

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10
Q

Ankylosing spondylitis is associated with which HLA antigen?

A

HLA - B27

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11
Q

Goodpastures Is associated with which HLA antigen?

A

HLA-DR2

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12
Q

What immunoglobulin is the least abundant isotype in blood serum

A

IgE

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13
Q

C5-9 Deficiency predisposes to what?

A

Neisseria meningitidis infection

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14
Q

What is the function of Interferon-γ?

A

Activates macrophages

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15
Q

Sjogren’s syndrome is associated with which HLA antigen?

A

HLA-DR3

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16
Q

Narcolepsy Is associated with which HLA antigen?

A

HLA-DR2

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17
Q

Leiners disease is due to a deficiency in what compliment

A

C5

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18
Q

What is the most commonly produced immunoglobulin in the body?

A

IgA

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19
Q

C5 Deficiency predisposes to what?

A

Leiner disease: recurrent diarrhoea, wasting and seborrhoeic dermatitis

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20
Q

What is the function of IgD?

A

Role in immune system largely unknown
Involved in activation of B cells

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21
Q

Coeliac disease is associated with which HLA antigen?

A

HLA - DQ2/DQ8

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22
Q

What is the function of Tumour necrosis factor-α?

A

Induces fever
Neutrophil chemotaxis

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23
Q

Behcet’s Disease is associated with which HLA antigen?

A

HLA - B51

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24
Q

What is the function of Interleukin 6?

A

Stimulates differentiation of B cells
Induces fever

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25
What is the function of Interleukin 2?
Stimulates growth and differentiation of T cells
26
What is the function of Interleukin 8?
Neutrophil chemotaxis
27
HLA-DR3 Is associated with which conditions?
dermatitis herpetiformis Sjogren's syndrome primary biliary cirrhosis
28
Dermatitis Herpetiformis is associated with which HLA antigen?
HLA-DR3
29
C1q, C1rs, C2, C4 deficiency predisposes to what?
Immune complex disease e.g. SLE, Henoch-Schonlein Purpura
30
What is the function of Interleukin 1?
Acute inflammation Induces fever
31
HLA-DR2 Is associated with which conditions?
narcolepsy Goodpasture's
32
Reactive arthritis is associated with which HLA antigen?
HLA - B27
33
Recurrent bacterial infections may be due to what compliment deficiency
C3
34
Haemochromatosis is associated with which HLA antigen?
HLA - A3
35
What is the function of Interleukin 12?
Activates NK cells and stimulates differentiation of naïve T cells into Th1 cells
36
Psoriatic arthritis is associated with which HLA antigen?
HLA - B27
37
What is the predominant immunoglobulin found in breast milk. It is also found in the secretions of digestive, respiratory and urogenital tracts and systems?
IgA
38
What is the function of IgA?
Provides localized protection on mucous membranes
39
What is the function of Interleukin 5?
Stimulate production of eosinophils
40
HLA - B27 is associated with which conditions?
Ankylosing spondylitis Reactive arthritis Acute anterior uveitis Psoriatic arthritis
41
Acute anterior uveitis is associated with which HLA antigen?
HLA - B27
42
What is the function of Interleukin 10?
Inhibits Th1 cytokine production ( the anti-inflamatory Cytokine)
43
Deficiency in what compliment predisposes to Neisseria meningitidis infection
C5-9
44
Primary biliary cirrhosisis associated with which HLA antigen?
HLA-DR3
45
C3 Deficiency predisposes to what?
Recurrent bacterial infections
46
What is the function of Interleukin 4?
Stimulates proliferation and differentiation of B cells
47
What is the function of IgE?
Mediates type 1 hypersensitivity reactions Synthesised by plasma cells Binds to Fc receptors found on the surface of mast cells and basophils Provides immunity to parasites such as helminths
48
What is the function of IgM?
Fixes complement but does not pass to the fetal circulation Anti-A, B blood antibodies
49
HLA - DQ2/DQ8 is associated with which Disease?
Coeliac disease
50
Deficiency in what compliment causes hereditary angioedema
C1 inhibitor (C1-INH) deficiency
51
What is the function of IgG?
Enhance phagocytosis of bacteria and viruses Fixes complement and passes to the fetal circulation
52
What is the function of CD1?
MHC molecule that presents lipid molecules
53
What is the function of CD2?
Found on thymocytes, T cells, and some natural killer cells that acts as a ligand for CD58 and CD59 and is involved in signal transduction and cell adhesion
54
What is the function of CD3?
The signalling component of the T cell receptor (TCR) complex
55
What is the function of CD4?
Found on helper T cells. Co-receptor for MHC class II Used by HIV to enter T cells
56
What is the function of CD5?
Found in the majority of mantle cell lymphomas
57
What is the function of CD8?
Found on cytotoxic T cells. Co-receptor for MHC class I Found on a subset of myeloid dendritic cells
58
What is the function of CD14?
Cell surface marker for macrophages
59
What is the function of CD15?
Expressed on Reed-Sternberg cells (along with CD30)
60
What is the function of CD16?
Bind to the Fc portion of IgG antibodies
61
What is the function of CD21?
Receptor for Epstein-Barr virus
62
What is the function of CD28?
Interacts with B7 on antigen presenting cell as costimulation signal
63
What is the function of CD45?
Protein tyrosine phosphatase present on all leucocytes
64
What is the function of CD56?
Unique marker for natural killer cells
65
What is the function of CD95?
Acts as the FAS receptor, involved in apoptosis
66
Where does Type 1 Collagen most appear and what is the associated condition?
Bone, skin, tendon Osteogenesis imperfecta
67
Where does Type 2 Collagen most appear and what is the associated condition?
Hyaline cartilage, vitreous humour None
68
Where does Type 3 Collagen most appear and what is the associated condition?
Reticular fibre, granulation tissue Vascular variant of Ehlers-Danlos syndrome
69
Where does Type 4 Collagen most appear and what is the associated condition?
Basal lamina, lens, basement membrane Alport syndrome , Goodpasture's syndrome
70
70
Where does Type 5 Collagen most appear and what is the associated condition?
Most interstitial tissue, placental tissue Classical variant of Ehlers-Danlos syndrome
71
Signet Ring Cells are associated with what type of cancer?
Gastric Adenocarcinoma
72
Signet Ring Sign is associated with what Pathology?
Seen on CT in Bronchiectasis

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