Brainscape's Knowledge GenomeTM


Top Flashcards (Certified)
All Flashcards

2 - CPR (pulmonary) > Asthma and COPD Drugs (cont.) > Flashcards

Asthma and COPD Drugs (cont.) Flashcards

(50 cards)

Start Studying
1
Q

MOA for Beta 2 Agonists?

A

Active Beta 2 receptors to relax smooth muscle and cause bronchildation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

What are some possible adverse effects with the use of Albuterol?

A

Insomnia, dry mouth, cough

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Which SABA is the only one available by Subcutaneous Injection?

A

Terbutaline

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

How is Terbutaline given?

A

SubQ injection

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Patient with what allergy should not use Terbutaline (SABA)?

A

Sulfur allergy patients

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

What are the main adverse effects seen with the use of Terbutaline?

A

Tachycardia and palpitations

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

What are the main system effects of Pirbuterol (SABA)?

A

CV effects

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Which 3 SABA have the risk of causing paradoxical bronchospasm and CV effects?

A

Albuterol
Metaproterenol
Levalbuterol

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Which 3 SABA have the risk of causing paradoxical bronchospasm?

A

Albuterol
Metaproterenol
Levalbuterol

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

LABA are more often used in the treatment of COPD. If they are used in patients with asthma, what must that patient be using too?

A

Asthmatic patients must also be using an ICS!!

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

In order for LABAs to be used with Asthma patients, what must they also be using?

A

ICS

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Why must patients with asthma be using an ICS in order to use a LABA?

A

Increases the risk of asthma related deaths if not using an ICS as well

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

MOA for Anticholinergic drugs?

A

Block Acetylcholine from binding its receptors => bronchodilation by (-) parasympathetics

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Which Anticholinergic drug is used for a TEMPORARY blockade of muscarinic effects?

A

Atropine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

In patients with CAD, what must the Atropine dose be less than and why?

A

Less than 2-3 mg to avoid an increased HR and myocardial oxygen demand

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Which Anticholinergic drug is used for the maintenance treatment of Bronchospasm?

A

Ipratropium

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

What is unique about Ipratropium?

A

It is poorly absorbed so it is relatively free of systemic atropine-like side effects!!

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

Which 2 Anticholinergic drugs are used for the LONG-term maintenance of bronchospasm?

A

Tiotropium

Aclidinium

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

Which 2 Anticholinergic drugs are used for the long-term maintenance of bronchospasm?

A

Tiotropium

Aclidinium

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

What are the 2 MOAs for Theophylline (methylxanthine)?

A
  1. Bronchodilation

2. Suppresses airway response to stimuli

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

What conditions can Methylxanthines possible exacerbate?

Study These Flashcards
A

PUD
Seizure disorders
Cardiac arrhythmias

22
Q

Which Methylxanthine can bronchodilate and suppress airway response to stimuli?

23
Q

What class of drugs is the most effective controller of Asthma?

24
Q

ICS decrease what cells?

Study These Flashcards
A

Eosinophils
Mast cells
T lymphocytes

25
MOA for ICS?
Turn off transcription of genes that encode inflammatory proteins
26
MOA for ICS?
Turn off transcription of genes that encode inflammatory proteins
27
For patients with persistent asthma, what is the 1st line therapy and what can you add after that?
ICS | +/- LABA
28
With what 2 drugs must you be careful when switching them off a systemically active corticosteroid to the ICS?
Beclomethasone | Triamcinolone
29
Why must you be careful when switching patients off a systemically active corticosteroid to either Beclomethasone or Triamcinolone?
Deaths due to adrenal insufficiency have occurred
30
What 2 ICS drugs should patients who have a hypersensitivity to milk proteins avoid?
Budesonide | Mometasone
31
What 2 ICS drugs should patients with a hypersensitivity to milk proteins avoid?
Budesonide | Mometasone
32
Ciclesonide is a ____ that is (+) by _____
Prodrug | (+) bronchial esterases
33
Since Ciclesonide is a prodrug, what does that decrease the risk of?
Candidiasis
34
Flunisolide may reduce the need for what drug?
ORAL corticosteroids
35
Triamcinolone may reduce the need for what drug?
Systemic corticosteroids
36
What is a possible adverse effect of Fluticasone and what should patients do after drug use?
Candida Albicans infection of mouth/pharynx | -- have patients rinse mouth after use
37
ICS drugs are NOT to be used in what conditions?
Status asthmaticus or severe acute asthma
38
ICS drugs are NOT to be used in what conditions?
Status asthmaticus or severe acute asthma
39
Oral corticosteroids are more likely to cause what compared to ICS?
Side effects
40
To treat asthma flare-ups, what can be added to a SABA?
Oral corticosteroid
41
Prednisone adverse effect?
Hypothalamic-Pituitary-Adrenal axis suppression
42
Patients on prednisone should be monitored for what?
Cushings Syndrome and hyperglycemia
43
MOA of Leukotriene Antagonists?
Block CysLT receptors and their subsequent inflammatory cascade
44
Montelukast blocks what receptor and what specific Leukotriene from performing its actions?
CysLT1 receptor | -- LTD4
45
Zafirlukast blocks the actions of what leukotrienes?
LTD4 and E4
46
What is an adverse effect of Zafirlukast?
Hepatotoxcity
47
Zileuton is a lipoxygenase (-) which means it blocks for the formation of?
All leukotrienes - LTB4, C4, D4, E4
48
In what condition is Zileuton controlled release form NOT recommended?
Liver disease and elevated liver enzymes 3X ULN
49
What type of Antibody is Omalizumab and what does a patient have to have in order to be placed on it?
Anti-IgE antibody - (+) skin test OR - reactivity to perennial aeroallergen
50
Adverse effect of Omalizumab?
Anaphylaxis

2 - CPR (pulmonary) (26 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2025 Bold Learning Solutions. Terms and Conditions