Asthma/COPD drugs Flashcards Preview

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Flashcards in Asthma/COPD drugs Deck (92)
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1

Albuterol

Ventolin

2

What class of drug is Abuterol?

Beta-2 Adrenergic Agonist

3

By what pathway does albuterol cause bronchodialation?

Stimulates Gs and Adenyl Cyclase --> increase cAMP-->activated PKA--->which phosphorylates myosin LC kinase causing bronchodialation

4

Terbutaline

Brethine

5

What class of drug is terbutaline?

Beta-2 adrenergic agonist

6

What is the rate of onset of albuterol?

inhalation--> 5 min
oral --> 30 min

7

What is the duration of albuterol?

inhalation --> 3-4 hours
oral --> 3-8 hours

8

What is the rate of onset of terbutaline?

inhalation --> 5 min
oral --> 30 min

9

What is the duration of action of terbutaline?

Inhalation --> 3-6 hours
oral --> 3-8 hours

10

Salmeterol

Severent

11

what class of drugs does salmeterol belong too?

Beta-2 adrenergic agonists

12

what is the rate of onset of salmeterol?

inhalation--> > 20 min

13

What is the duration of action of salmeterol?

12 hours

14

Formoterol

foradil, brovana

15

What class does formoterol belong too?

Beta-2 adrenergic agonists

16

What is the rate of onset of formoterol?

<10 min

17

What is the duration of action of formoterol?

>12 hours

18

Which B2 agonists are only for use in combination with glucocorticoids?

Salmeterol and formoterol

19

What are ADE associated with B2 adrenergic agonists?

- Skeletal muscle tremors
- Tachycardia & palpitations
( less with B2 selective agents)

20

by what mechanism does B2 adrenergic agonists cause tachycardia and palpitations?

High doses can stimulate B1 receptors in the heart
Reflex tachycardia from baroreceptors (caused by drop in BP due to vaso/bronchodialation)

21

True or False?
Salmeterol and formoterol are contraindicated as monotherapy?

True

22

LABAs

Salmeterol/formoterol

23

SABAs

Albuterol/terbutaline

24

What is the mechanism of glucocorticoids?

Decrease protein synthesis
- causes decreased esinophils/macrophages/mast cells
- decreased prostaglandin/leukotryine syntheses
- decreased hyperresponsiveness of bronchiole smooth muscle

25

How are inhaled glucocortocoids dosed?

One inhalation in the morning

26

What type of infection does glucocorticoid use perpetuate?

Fungal thrush infections

27

What class of drugs does Advair belong too?

Glucocorticoid Combo

- inhaled steroid + LABA

28

Advair

Fluticasone + salmeterol combo

29

What are the doses of advair?

100,250,500 ug of fluticasone
50 ug salmeterol

30

Symbicort

budesonide + formoterol