Gout Pathophysiology Flashcards Preview

Therapeutics Spring 2015 > Gout Pathophysiology > Flashcards

Flashcards in Gout Pathophysiology Deck (35)
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1

What kind of crystals get deposited in the synovial fluid/tissues?

monosodium urate crystals

2

True or false? Is there a correlation between the uric acid level and the incidence and prevalence of gout?

True

3

What serum urate level is correlated with hyperuricemia?

> 6.8 mg/dL

4

What is hyperuricemia?

The pre-clinical version of gout

5

Which joint is the most common joint for gout attacks?

The metatarsal felangeal joint

6

What are some risk factors for increasing serum urate concentration?

Age (peaks at 30-50 yo)
SCr/BUN
Male (3 x more than women)
BP
Body weight
Alcohol

7

What percentage of US adults have hyperuricemia?

21%

8

Which percentage of adults with hyperuricemia develop gout?

20% (many remain asymptomatic)

9

Which percentage of adults with hyperuricemia develop gout?

20% (many remain asymptomatic)

10

Which enzyme converts hypoxanthine to xanthine?

Xanthine Oxidase

11

Which enzyme converts xanthine to uric acid?

Xanthine Oxidase

12

Do humans have uricase?

No, only animals. We have the non functional gene

13

Do humans have uricase?

No, only animals. We have the non functional gene

14

Do humans have uricase?

No, only animals. We have the non functional gene

15

Which enzyme converts inosinic acid to hypoxnthine?

purine nucleoside phosphoylase

16

Increased _____ synthetase activity increases the De Novo synthesis of purines?

PRPP synthetase

17

AMP, IMP and GMP block what?

de novo synthesis of purines

18

PRPP gets converted to what by 10 steps?

IMP

19

Decreased HGPRTase activity causes what?

increased hypoxanthine OX
De novo synthesis through increased PRPP

20

Is gout a familial disease?

Yes

21

Gout causes what kind of arthritis?

Acute

22

What inflammatory mediators do synoviocytes release?

prostaglandins, lysosomal enzymes nd IL-1

23

What inflammatory mediators do synoviocytes release?

prostaglandins, lysosomal enzymes and IL-1

24

Which granulocytes appear early on in inflammation?

neutrophils

25

What APC appears later on in gout?

macrophages

26

What plasma urate is correlated with symptomatic hyperuricemia in males?

> 7.0 mg/dL

27

What plasma urate is correlated with symptomatic hyperuricemia in females?

> 6.0 mg/dL

28

What plasma urate is correlated with symptomatic hyperuricemia in females?

> 6.0 mg/dL

29

What is the sign of acute gout?

Acute arthritis in the first metatarsophlangeal joint

30

What is the pharmacological intervention for acute gout?

colchicine