Asymmetric Synthesis Flashcards
How do you calculate enantiomeric excess from the molar ratios of two enantiomers?
How do you calculate the molar ratios of two enantiomers from the enantiomeric excess?
Draw the transitionstate when a carbonyl containing compound reacts with R-CBS and BH3
Write down the mnemonic for R-CBS
What controls the face of epoxation when using m-CPBA?
Attacks from the least hindered site unless directed by hydrogen bonding
Which side does (+/-)-tartrate add the epoxide to?
(-)-tartrate - top face
(+)-tartrate - bottom face
Draw the mnemonic for sharpless epoxidation
Draw the transition state for sharpless epoxidation
Write down the mnemonic for salen molecules
if you have 2-cyclohexenol and you want to Hydroxylate it with OsO4 how do you control which face is added to and why?
TMEDA adds e- density allowing for hydrogen bonding and dihydroxilating the same face.
Otherwise sterics will cause it to happen on the least hindered face
Write down the mnemonic for AD mixes
When the stereochemistry for an enolate to form an aldol is controled with a metal, what do the transition states look like and how does it effect the product?
