Flashcards in ataxia Deck (11):
dysfunction in which part of the brain is associated with ataxia?
controls the timing and pattern of motor activity during movement
ataxio=lack of order
dysfunction of which cells are associated with dysfunction in ataxia?
maybe insert diagram?
what are the symptoms of cerebellar dysfunction?
slurring of speech ( staccato)
loss of movement precision
unsteadiness when walking (worse in dark)
what are the signs of cerebellar dysfunction
what is nystagmus?
abnormalities of eye movements
what are the 6 classifications of ataxias?
1) congenital (eg cerebellar dysgenesis
2) disease where ataxia is one of many features (usually autosomal recessive diseases)
3) episodic ataxias (eg EA1,1...)
4) autosomal recessive (FA)
5) autosomal dominant (eg SCAs)
6) sporadic ataxias (eg MSA-C, gluten ataxia)
does not include structural damage ataxia
what history features should be taken for ataxia?
age of onset
rate of progression
additional features (genito-urinary, postural)
pattern of involvement
detailed family history
exposure to drugs toxic to the cerebellum
what examinations should be performed for ataxias?
eye involvement (nystagmus, broken pursuit)
symmetrical vs unilateral
evidence of peripheral neuropathy or sensory
neuronopathy (sensory ataxia)
evidence of postural blood pressure fall
what radiological investigation is useful for ataxias?
white matter involvement in leukodystrophy
list some causes of ataxia
clinically probably MSA-C
anti-GAD associated ataxia