Flashcards in guillian barre syndrome Deck (25):
what is guillian barre syndrome?
an acute demyelinating polyneuropathy
how does the classic guillian barre patient present?
viral infection or diarrhoe prodrome (75%)
few weeks later becomes weak over days
first legs than arms
mild sensory changes
can be facial, bulbar and/or respiratory weakness
signs of lower motor neuron dysfunction
what does lower motor neuron dysfunction indicate in guillian barre?
what does the LP for guillian barre show?
what does the NCS for guillian barre show?
what are the LMN lower motor neurone problem sings
distally weak (sometimes pyramidal)
plantar responses flexor or absent
what is chronic inflammatory demyelinating polyneuropathy?
chronic demyelinating neruopathy similar to guillain barre
how does CIDP, chronic inflammatory demyelinating polyneuropathy typically present?
similar to GBS but slower
not usually prodrome (ie diarrhea) OR resp failure
LP high protein, NCS demyelination
facial weakness and opthalmoparesis
how is CIDP treatable?
good evidence for steroids (lancet 2006)
steroid sparing agents may be useful
in what ways is CIDP different to guillian barre?
doesnt usually occur with prodrome
is chronic rather than acute
GBS does not respond to steroids
what point is nadir in CIDP and GBS?
guillian barre 8 weeks
what tree conditions could be used to describe the continuum between GBS and CIDP
acute inflammatory demyelinating polyneuropathy (AIDP)
subacute inflammatory demyelinating polyneuropathy (SIDP)
chronic inflammatory demyelinating polyneuropathy (CIDP)
how is guillian barre treatable?
what is the incidence of guillian barre?
2 per 100,000
specifically, how does GBS present?
ascending symmetrical weakness hours to days
LMN signs +/- mild sensory signs
what are the GBS mimics?
acute spinal cord lesion
crtical illness polyneuropathy
HIV, lyme (rare)
what are the GBS chameleons?
what tests should be performed for GBS and CIDP?
nerve conduction study (demyelination)
MRI (Exclude cord lesions)
in rare cases what antibody can be testes for in guillian barre?
what happens to the F wave in GBS?
what is prognosis for GBS?
most patients fully recover
what age does CIDP mostly affect?
any age but mostly 40-60
what is the incidence of CIDP?
what two types of CIDP are they?
relapsing and progressive