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Flashcards in myelin damage and recovery Deck (10):
1

name five demyelinating diseases

Multiple sclerosis
ADEM
Transverse myelitis
Optic neuritis
Neuromyelitis optica

2

what has research told us about what happens in MS?

Inflammation occurs
axonal damage occurs
demyelination occurs and remyelination occurs

3

name 6 features of neuroplasticity

Dendritic absorption
New synapses form
Reorganisation of existing pathways
sodium channel redistribution
axonal sprouting

4

what is the prevalence of neuromyelitis optica?

0.6 per 1000
(95% recover)

5

what are some possible explainations as to why some people with neuromyelitic optica recover and others fail to?

More severe inflammation?
More demyelination?
More neuroaxonal loss?
More damage elsewhere?
Less remyelination?
Less tissue reserve (i.e. less redundancy)?
Less neuroplasticity?

6

Optical coherence tomography (OCT) can be used to measure what?

axonal damage

7

Gadolinium-enhanced MRI is a measure of?

inflammation

8

Diffusion-weighted MRI of the optic radiations is used to measure?

tract integrity

9

MRI measurements of cortical thickness and atrophy is a measure of what?

neuroaxonal loss

10

functional MRI can be used to measure what?

neuroplasticity