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Flashcards in Atherosclerosis 2 Deck (8)
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How bad is diabetes for CHD risk? (what's a useful comparison)

Diabetes increases risk for CHD by 20%. This is equivalent to that caused by having had a prior MI.
So it's bad.


Metabolic syndrome is considered a significant risk factor for CHD. How is metabolic syndrome defined?

At least of the 3 of the following 5 conditions:
Central obesity (by waist circumference).
High TGs. (>150mg/dL)
Low HDL. (85 dias).
High fasting glucose (>110mg/dL).

(note that some of these don't meet the cutoffs for HTN or T2DM)


Are increased levels of inflammatory molecules associated with increased risk of CVD?



Would lowering CRP directly (say... with an anti-CRP antibody, or something) affect CVD risk?

Probably not. Genetic studies suggest that CRP is a marker of increased CVD risk, but does not itself drive CVD.


What does Lp-PLA2 do, and what does it have to do with atherosclerosis?

Lipoprotein phospholipase A2 breaks down lipids stored in LDL into pro-inflammatory / atherogenic peptides.
Drugs targeting it are in Phase III trials.


4 methods for non-invasive (i.e. not cardioangiogram) screening for subclinical atherosclerosis? (What does each technique assess?)

B-mode ultrasonography (intimal thickening/proliferation)
Electron beam tomography or CT (to assess calcification)
MRI (plaque size and morphology)
Molecular imaging (not sure what this is getting at... assessment of expression of molecules like ICAM / VCAM??)


What protease was identified in GWASs / other large studies as being a significant risk factor for CHD?

ADAMTS7 - overexpression may lead to fibrous cap thinning and increased risk for plaque rupture. A good potential drug target.


Interesting things are being identified in these large genetic studies.