Autacoids

Question 1

Subgroups of 1st Generation antihistamines:

Answer 1

Ethanolamines
Piperazines
Phenothiazine
Alkylamines

Question 2

The Ethanolamines (1stGenHis):

Answer 2

Diphenhydramine (Benadryl)
Dimenhydrinate (Dramamine)
Doxylamine (Unisom)

Question 3

The Piperazines (1stGenHis):

Answer 3

Hydroxyzine (Iterax)

Meclizine (Bonamine)

Question 4

1stGenHis that causes orthostatic hypotension:

Answer 4

Promethazine (Phenothiazine)

Question 5

1stGenHis with less sedative effects:

Answer 5

Chlorpheniramine (Alkylamines)

Question 6

Bioflu is composed of:

Answer 6

Chlorpheniramine
Paracetamol
Phenylephrine (anti-emetic)

Question 7

Adverse effects of 1stGenHis:

Answer 7

1) Sedation (less with 2nd Gen)
2) Cholinergic receptor blockade
3) Alpha adrenoreceptor blockade (orthostatic hypotension
4) GIT effects

Question 8

Subgroups of 2nd Generation Antihistamines:

Answer 8

Piperidines
Piperazines
Phthalazinone (Azelastine)

Question 9

Members of 2nd Gen Piperidines:

Answer 9

Fexofenadine (Allegra)
Loratidine
Desloratadine

Question 10

Members of 2nd Gen Piperazines:

Answer 10

Cetirizine (Zyrtec)

Levocetirizine

Question 11

Treatment for urticaria:

Answer 11

Diphenhydramine (benadryl) or loratidine

Question 12

Ophthalmic solution for allergic conjunctivitis:

Answer 12

Azelastine

Question 13

Anti motion sickness antihistamines:

Answer 13

Diphenhydramine
Dimenhydrinate
Meclizine

Question 14

Antihistamine used as anti-emetic:

Answer 14

Promethazine

Question 15

Anti-parkinsonism anti histamine:

Answer 15

Diphenhydramine injection

Question 16

Hypnotic antihistamines:

Answer 16

Doxylamine

Diphenhydramine

Question 17

MOA of 5-HT Receptor Agonists (Triptans):

Answer 17

Activate 5 HT 1D/1B receptors on cranial arteries
Inhibit release of vasodilating peptides
Constrict cerebral blood vessels

Question 18

5 HT Receptor antagonists:

Answer 18

Ondansetron (5-HT3)

Cyproheptadine (5HT2 & H1)

Question 19

Uses of Ondansetron:

Answer 19

Prevent and treat nausea and emesis associated with cancer treatment

Question 20

Uses of Cyproheptadine:

Answer 20

Anti-serotonin and anti-histamine effect

Treats cold induced urticaria

Question 21

Used to stimulate uterine smooth muscle:

Answer 21

Ergonovine (5HT2)

Methylergonovine (5HT2)

Question 22

Combined with caffeine to facilitate absorption, produces vasoconstriction to treat acute migraine:

Answer 22

Ergotamine (5HT2)

Dihydroergotamine (5HT2)

Question 23

MOA of Misoprostol (PGE) (Cytotec):

Answer 23

Inhibits secretion of gastric acid

Stimulates uterine contractions

Question 24

Uses of carboprost (PGF2a):

Answer 24

Terminate early stage pregnancy
Induce labor
Treat postpartum bleeding

Question 25

Prostaglandin analog used to decrease intra-ocular pressure:

Answer 25

Latanoprost (PGF2a) Bimatoprost Travoprost

Question 26

Alprostadil is used to:

Answer 26

Maintain the patency of ductus arteriosus after birth | Relax the corpora cavernosal smooth msucles

Question 27

Ethanolamines effects are characterized by:

Answer 27

Marked sedation Strong muscarinic block Low incidence of adverse GIT effects

Question 28

Piperidines effects are characterized by:

Answer 28

Highly selective for H1 receptors | Less anticholinergic effects

Question 29

Fexofenadine is a metabolite of ___ which was known to cause:

Answer 29

Terfendadine; cardiac arrhythmia

Question 30

2nd Gen Piperazines are characterized by their:

Answer 30

Minimal anticholinergic effects

Question 31

5-HT Receptor Agonists:

Answer 31

Triptans (5HT1D/1B) Buspirone (anxiolytic) (5HT1A) Pricalopride (chronic constipation) (5HT4)