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Principles of Disease > Auto-Immune Diseases > Flashcards

Auto-Immune Diseases Flashcards

(60 cards)

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1
Q

Autoimmune Hemolytic Anemia(AIHA) auto-antibody

A

anti-RBC antibodies

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2
Q

Autoimmune Hemolytic Anemia(AIHA) clinical signs

A

RBC hemolysis

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3
Q

Autoimmune Hemolytic Anemia(AIHA) clinical test

A

Positive Direct Coombs Test

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4
Q

Pemphigus Vulgaris auto-antibody

A

anti-desmoglein (desmosomes)

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5
Q

Pemphigus Vulgaris pathogenesis

A

IgG mediated disruption of cellular adhesion on skin and mucosa

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6
Q

Pemphigus Vulgaris clinical presentation

A

blisters all over body fishnet pattern in Immunofluorescence

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7
Q

Goodpasture’s Syndrome auto-antibody

A

anti-basement membrane in glomerulus and cross-reactivity with lung alveoli

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8
Q

Goodpasture’s Syndrome pathogenesis

A

IgG mediated complement activation and Fc receptor mediated inflammation

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9
Q

Goodpasture’s Syndrome clinical presentation

A

glomerulonephritis, lung hemorrhage

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10
Q

Goodpasture’s Syndrome treatment

A

Removing the anti-GBM antibody by plasmapheresis immunosuppressant drugs

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11
Q

Acute Rheumatic Fever auto-antibody

A

Strep A antibody cross-reacts with myocardial antigen

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12
Q

Acute Rheumatic Fever pathogenesis

A

macrophage activation and inflammation

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13
Q

Acute Rheumatic Fever clinical presentation

A

myocarditis and arthritis

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14
Q

Pernicious Anemia auto-antibody

A

anti-Intrinsic Factor (Parietal Cells)

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15
Q

Pernicious Anemia Pathogenesis

A

Neutralization of Intrinsic Factor Decreased Vit B12 absorption

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16
Q

Pernicious Anemia clinical presentation

A

abnormal erythropoiesis and anemia

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17
Q

Myasthenia Gravis auto-antibody

A

anti-Acetylcholine Receptor

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18
Q

Myasthenia Gravis Pathogenesis

A

antibody inhibits ACh binding down-modulates receptors

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19
Q

Myasthenia Gravis clinical presentation

A

muscle weakness PTOSIS

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20
Q

Grave’s Disease auto-antibody auto-antibody

A

anti-TSH Receptor

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21
Q

Grave’s Disease Pathogenesis

A

antibody stimulates TSH secretion

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22
Q

Grave’s Disease clinical presentation

A

enlarged thyroid/goiter bulging eyes

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23
Q

Serum Sickness hypersensitivity type and pathogenesis (timing after exposure and mechanism)

A

Type III antibodies to foreign proteins are produced 5-10 days after exposure Immune complexes deposit in membranes complement activation leads to damage

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24
Q

Complement serum levels in Serum Sickness?

A

decrease due to activation

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25
Serum Sickness presentation
rash fever arthritis
26
Rheumatic Arthritis auto-antibody and pathogenesis
IgM antibody that targets IgG Fc region Rheumatoid Factor deposits in joints, causes inflammation
27
SLE auto-antibody
anti-dsDNA
28
SLE pathogenesis
Ag/Ab complexes damage tissues by activating complement
29
SLE presentation
butterfly rash after sunlight exposure systemic inflammation women more affected
30
Polyarteritis nodosa pathogenesis and presentation
Formation of immune complexes in patients with circulating hepatitis B antigen vasculitis
31
anti-RBC antibodies
Autoimmune Hemolytic Anemia(AIHA) auto-antibody
32
RBC hemolysis
Autoimmune Hemolytic Anemia(AIHA) clinical signs
33
Positive Direct Coombs Test
Autoimmune Hemolytic Anemia(AIHA) clinical test
34
anti-desmoglein (desmosomes)
Pemphigus Vulgaris auto-antibody
35
IgG mediated disruption of cellular adhesion on skin and mucosa
Pemphigus Vulgaris pathogenesis
36
blisters all over body fishnet pattern in Immunofluorescence
Pemphigus Vulgaris clinical presentation
37
anti-basement membrane in glomerulus and cross-reactivity with lung alveoli
Goodpasture's Syndrome auto-antibody
38
IgG mediated complement activation and Fc receptor mediated inflammation
Goodpasture's Syndrome pathogenesis
39
glomerulonephritis, lung hemorrhage
Goodpasture's Syndrome clinical presentation
40
Removing the anti-GBM antibody by plasmapheresis immunosuppressant drugs
Goodpasture's Syndrome treatment
41
Strep A antibody cross-reacts with myocardial antigen
Acute Rheumatic Fever auto-antibody
42
macrophage activation and inflammation
Acute Rheumatic Fever pathogenesis
43
myocarditis and arthritis
Acute Rheumatic Fever clinical presentation
44
anti-Intrinsic Factor (Parietal Cells)
Pernicious Anemia auto-antibody
45
Neutralization of Intrinsic Factor Decreased Vit B12 absorption
Pernicious Anemia Pathogenesis
46
abnormal erythropoiesis and anemia
Pernicious Anemia clinical presentation
47
anti-Acetylcholine Receptor
Myasthenia Gravis auto-antibody
47
antibody inhibits ACh binding down-modulates receptors
Myasthenia Gravis Pathogenesis
47
muscle weakness PTOSIS
Myasthenia Gravis clinical presentation
47
anti-TSH Receptor
Grave's Disease auto-antibody auto-antibody
48
antibody stimulates TSH secretion
Grave's Disease Pathogenesis
48
enlarged thyroid/goiter bulging eyes
Grave's Disease clinical presentation
49
Type III antibodies to foreign proteins are produced 5-10 days after exposure Immune complexes deposit in membranes complement activation leads to damage
Serum Sickness hypersensitivity type and pathogenesis (timing after exposure and mechanism)
49
decrease due to activation
Complement serum levels in Serum Sickness?
49
rash fever arthritis
Serum Sickness presentation
49
IgM antibody that targets IgG Fc region Rheumatoid Factor deposits in joints, causes inflammation
Rheumatic Arthritis auto-antibody and pathogenesis
49
anti-dsDNA
SLE auto-antibody
49
Ag/Ab complexes damage tissues by activating complement
SLE pathogenesis
49
butterfly rash after sunlight exposure systemic inflammation women more affected
SLE presentation
50
Formation of immune complexes in patients with circulating hepatitis B antigen vasculitis
Polyarteritis nodosa pathogenesis and presentation

Principles of Disease (8 decks)

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