Paraneoplastic Syndromes Flashcards
(32 cards)
Small Cell Lung Cancer Pancreatic Cancer Neural Tumors Cause what paraneoplastic syndrome through what mechanism?
Cushings Disease ACTH
Lung Small Cell Carcinoma and intracranial neoplasms Cause what paraneoplastic syndrome through what mechanism?
SIADH ADH or ANP
Lung Squamous Cell Ca Breast Ca Renal Cell Ca Adult T-Cell Leuk/Lymph Cause what paraneoplastic syndrome through what mechanism?
Hypercalcemia PTH-related protein (PTHRP) , TGF-α, TNF, IL-1
Ovarian Cancer Cause what paraneoplastic syndrome through what mechanism?
Hypoglycemia Insulin or insulin-like substance
Hepatocellular ca Lung carcinoid Pancreatic ca Cause what paraneoplastic syndrome through what mechanism?
Carcinoid Syndrome Serotonin, bradykinin
Gastric ca Renal ca Cerebellar hemangioma Hepatocellular ca Cause what paraneoplastic syndrome through what mechanism?
Polycythemia Erythropoieitin
What syndrome is provoked by a lung cancer in 50-70% of cases that causes paraneoplastic production of antibodies to voltage gated calcium channels in nerve endings.
Lambert Eaton Syndrome
Clinical Scenario: Periosteal new bone at distal ends of long bones, hands, feet, and proximal phalanges Arthritis of adjacent joints Clubbing of digits Syndrome and cancer associated
HYPERTROPHIC OSTEOARTHROPATHY bronchogenic carcinoma
DISSEMINATED INTRAVASCULAR COAGULATION (DIC) cancers (2) associated
Acute promyelocytic leukemia, prostate cancer
MARANTIC endocarditis is on what valve?
Mitral Valve
What are factors that cause cancer to be hyper-coagulable state? (3)
Increased clotting factors Increased inflammation Increased red cells and/or platelets
____ is the most thrombogenic cancer
MUCINOUS adenocarcinoma
What cancer is characterized with a “Napkin ring obstruction”
Colon tumors
What is a SENTINAL LYMPH NODE?
First node in a regional lymphatic system receiving lymph flow from tumor
In HEMATOGENOUS SPREAD where does colonization typically occur and what vessels are easily penetrated?
Tend to rest in first capillary bed encountered veins easily penetrated than arteries
____ is prolonged survival of micrometastases without progression
DORMANCY
Cushings Disease ACTH
Small Cell Lung Cancer Pancreatic Cancer Neural Tumors Cause what paraneoplastic syndrome through what mechanism?
SIADH ADH or ANP
Lung Small Cell Carcinoma and intracranial neoplasms Cause what paraneoplastic syndrome through what mechanism?
Hypercalcemia PTH-related protein (PTHRP) , TGF-α, TNF, IL-1
Lung Squamous Cell Ca Breast Ca Renal Cell Ca Adult T-Cell Leuk/Lymph Cause what paraneoplastic syndrome through what mechanism?
Hypoglycemia Insulin or insulin-like substance
Ovarian Cancer Cause what paraneoplastic syndrome through what mechanism?
Carcinoid Syndrome Serotonin, bradykinin
Hepatocellular ca Lung carcinoid Pancreatic ca Cause what paraneoplastic syndrome through what mechanism?
Polycythemia Erythropoieitin
Gastric ca Renal ca Cerebellar hemangioma Hepatocellular ca Cause what paraneoplastic syndrome through what mechanism?
Lambert Eaton Syndrome
What syndrome is provoked by a lung cancer in 50-70% of cases that causes paraneoplastic production of antibodies to voltage gated calcium channels in nerve endings.
HYPERTROPHIC OSTEOARTHROPATHY bronchogenic carcinoma
Clinical Scenario: Periosteal new bone at distal ends of long bones, hands, feet, and proximal phalanges Arthritis of adjacent joints Clubbing of digits Syndrome and cancer associated
